Using dextrose to reduce nausea after gynecological surgery

Research Investigator

This study is testing if giving a sugar solution through an IV after gynecological surgery can help reduce nausea and vomiting for patients recovering from anesthesia.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 108 (estimated)
• Ages: 18 Years to 75 Years
• Sex: Female
• Sponsor: Weifang Medical University (Academic / other)
• Locations: 1 site (Weifang, Shandong)
• Trial ID: NCT05932160 on ClinicalTrials.gov

What this trial studies

This study investigates whether intravenous dextrose infusion during recovery from anesthesia can decrease the occurrence of postoperative nausea and vomiting (PONV) in patients undergoing gynecological laparoscopic procedures. The trial will involve administering a 5% glucose solution alongside lactated ringers to eligible participants. The goal is to determine if this intervention can effectively mitigate PONV, which is a common complication following surgery. The study will include patients classified as ASA I or II who are undergoing general anesthesia for gynecological laparoscopic surgery.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 to 75 undergoing gynecological laparoscopic procedures under general anesthesia with ASA physical status I or II.

Not a fit: Patients with severe hypertension, diabetes mellitus, significant hepatic or renal disease, or those unable to follow the protocol may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could significantly reduce the incidence of postoperative nausea and vomiting in patients undergoing gynecological surgery.

How similar studies have performed: While the specific use of dextrose for PONV is less common, similar studies exploring intravenous fluids for nausea management have shown promising results.

Eligibility criteria

Inclusion Criteria:

1. ASA I or II;
2. Performing gynecologic laparoscopic procedures under general anesthesia;

Exclusion Criteria:

1. age \<18 or \>75
2. severe hypertension,diabetes mellitus, significant hepatic or renal disease
3. inability to follow protocol
4. refusal to participant

Where this trial is running

Weifang, Shandong

• Jiang Liu — Weifang, Shandong, China (Recruiting)

Study contacts

• Principal investigator: Jiang Liu, B.S — Weifang Medical University
• Study coordinator: Jiang Liu, B.S

Conditions Postoperative Nausea and Vomiting; PONV