Using dexmedetomidine to reduce postoperative delirium in brain tumor patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effects of dexmedetomidine on reducing the incidence of postoperative delirium in patients undergoing elective craniotomy for temporal glioma. The study will involve strict adherence to protocols, with data collected and monitored securely in an electronic database. The primary hypothesis is that dexmedetomidine can mitigate neuroinflammation, enhance postoperative pain management, and improve sleep quality, thereby decreasing the likelihood of delirium after surgery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with temporal glioma scheduled for a elective craniotomy
* Age ≥18 years
* Obtain written informed consent.

Exclusion Criteria:

* Patients with severe preoperative cognitive impairment
* History of traumatic brain injury or previous neurosurgery
* History of psychotropic medications
* Allergy to dexmedetomidine
* Pregnant or lactating women
* History of obstructive sleep apnoea syndrome
* Severe bradycardia(heart rate \<40 beats/min), sick sinus syndrome or second-to-third degree atrioventricular block
* Severe hepatic dysfunction
* Severe renal dysfunction

Where it's running

• Beijing Tiantan Hospital
  Beijing, China Recruiting

Study contacts

• Principal investigator: Yuming Peng — Beijing Tiantan Hospital
• Study coordinator: Yuming Peng
• Email: florapym766@163.com
• Phone: 0086+18601076588

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.