Using dexmedetomidine and magnesium sulfate to reduce cognitive issues in older adults after surgery
The Efficacy of Dexmedetomidine and Magnesium Sulfate in Cognitive Dysfunction
This study tests if using dexmedetomidine and magnesium sulfate during surgery can help older adults avoid memory and thinking problems after their operation.
Quick facts
| Phase | Phase 1 |
|---|---|
| Study type | Interventional |
| Enrollment | 58 (estimated) |
| Ages | 60 Years to 80 Years |
| Sex | All |
| Sponsor | Fayoum University Academic / other |
| Locations | 1 site (Al Fayyum) |
| Trial ID | NCT06702488 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to evaluate the effectiveness of dexmedetomidine and magnesium sulfate in preventing post-operative cognitive dysfunction (POCD) in elderly patients undergoing open abdominal surgery. The study will compare the neuroprotective effects of these two agents during general anesthesia, focusing on their impact on serum levels of CRP, a marker of neuronal degeneration. By investigating the relationship between these interventions and cognitive outcomes, the trial seeks to provide insights into improving post-surgical recovery in older adults.
Who should consider this trial
Good fit: Ideal candidates for this study are elderly patients classified as ASA physical status I, II, or III who are scheduled for open abdominal surgery under general anesthesia.
Not a fit: Patients with a preoperative MoCA score below 26 or those with a BMI over 35 kg/m² may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could significantly reduce the incidence of cognitive dysfunction in elderly patients after surgery.
How similar studies have performed: Previous studies have shown promising results regarding the neuroprotective effects of magnesium sulfate in similar contexts, suggesting potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * ASA physical status I, II and ⅠⅠⅠ * patients undergoing open abdominal surgery under general anesthesia Exclusion Criteria: * Elderly patients with preoperative MoCA Score below 26. * Operation time more than 4 hours to prevent excessive dosage of magnesium sulfate. * BMI \> 35 kg m-2
Where this trial is running
Al Fayyum
- Dexmedetomidine — Al Fayyum, Egypt (Recruiting)
Study contacts
- Study coordinator: Mohamed Ahmed Hamed, MD
- Email: mah07@fayoum.edu.eg
- Phone: 01010509736
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.