Using dexmedetomidine and magnesium sulfate to reduce cognitive issues in older adults after surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the effectiveness of dexmedetomidine and magnesium sulfate in preventing post-operative cognitive dysfunction (POCD) in elderly patients undergoing open abdominal surgery. The study will compare the neuroprotective effects of these two agents during general anesthesia, focusing on their impact on serum levels of CRP, a marker of neuronal degeneration. By investigating the relationship between these interventions and cognitive outcomes, the trial seeks to provide insights into improving post-surgical recovery in older adults.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* ASA physical status I, II and ⅠⅠⅠ
* patients undergoing open abdominal surgery under general anesthesia

Exclusion Criteria:

* Elderly patients with preoperative MoCA Score below 26.
* Operation time more than 4 hours to prevent excessive dosage of magnesium sulfate.
* BMI \> 35 kg m-2

Where it's running

• Dexmedetomidine
  Al Fayyum, Egypt Recruiting

Study contacts

• Study coordinator: Mohamed Ahmed Hamed, MD
• Email: mah07@fayoum.edu.eg
• Phone: 01010509736

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.