Using Dexamethasone to Prevent Post-surgery Bowel Issues After Cesarean Sections
Dexamethasone in the Prevention of Post-spinal Paralytic Ileus After Cesarean Section, Does it Make a Difference: A Randomized Controlled Study
PHASE1; PHASE2 · Assiut University · NCT05654649
This study is testing if giving Dexamethasone can help women aged 18-40 recover better from bowel issues after having a cesarean section.
Quick facts
| Phase | PHASE1; PHASE2 |
|---|---|
| Study type | Interventional |
| Enrollment | 90 (estimated) |
| Ages | 18 Years to 40 Years |
| Sex | Female |
| Sponsor | Assiut University (other) |
| Locations | 1 site (Asyut) |
| Trial ID | NCT05654649 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effectiveness of Dexamethasone in preventing postoperative ileus, a common complication following cesarean sections. The study will involve patients aged 18-40 who are undergoing elective or semi-elective surgeries under spinal anesthesia. Participants will receive either Dexamethasone or a saline solution to assess the impact on gastrointestinal recovery post-surgery. The trial aims to address the underlying mechanisms of postoperative ileus and improve recovery times for patients.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy women aged 18-40 with a singleton pregnancy scheduled for elective or semi-elective cesarean sections.
Not a fit: Patients with a BMI over 35, those with cardiovascular or severe renal/hepatic diseases, or those who cannot undergo regional anesthesia may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the incidence of postoperative ileus, leading to faster recovery and shorter hospital stays for patients after cesarean sections.
How similar studies have performed: While the use of Dexamethasone for postoperative recovery has been explored in other contexts, this specific application for preventing postoperative ileus after cesarean sections is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * •All participants will sign an informed consent prior to inclusion in the study. * All patients 18-40 years of full-term singleton pregnancy (37-41 weeks)., * American Society of Anaesthesiologists (ASA) classification class I and II scheduled. * for elective or semi-elective surgery (category 3 and 4 Caesarean sections). * All patients under spinal anesthesia for a Single baby pregnancy of more than 32 weeks will be included in this study. Exclusion Criteria: * will be patients' height \< 150 or \> 180 cm. * Body mass index (BMI) \>35 kg m-2. * Contraindication or refusal to undergo regional anesthesia. * any cardiovascular disease including arrhythmias and severe stenotic valvular heart disease.any renal or hepatic diseased patients.
Where this trial is running
Asyut
- woman health hospital , Assiut university — Asyut, Egypt (RECRUITING)
Study contacts
- Study coordinator: Ghada Abo Elfadl, MD
- Email: ghadafadl77@gmail.com
- Phone: 01005802086
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Postoperative Ileus