Using dexamethasone to prevent low blood pressure after spinal anesthesia in older patients undergoing orthopedic surgery
Effect of Dexamethasone on Post-spinal Hypotension in Geriatric Patients Undergoing Orthopaedic Surgery at Tertiary Care Hospital Karachi.
This study tests if giving dexamethasone before orthopedic surgery can help older patients avoid low blood pressure after receiving spinal anesthesia.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 170 (estimated) |
| Ages | 65 Years to 85 Years |
| Sex | All |
| Sponsor | Shaheed Mohtarma Benazir Bhutto Institue of Trauma Academic / other |
| Locations | 1 site (Karachi, Sindh) |
| Trial ID | NCT06819436 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effectiveness of intravenous dexamethasone in preventing post-spinal hypotension in geriatric patients undergoing orthopedic surgeries. Participants are divided into two groups: one receiving dexamethasone and the other receiving a placebo before their procedures. The study aims to determine if dexamethasone can significantly reduce the incidence of low blood pressure following spinal anesthesia. The trial is designed to provide insights into the management of hypotension in older adults during surgery.
Who should consider this trial
Good fit: Ideal candidates are geriatric patients undergoing orthopedic surgeries with an ASA classification of 2 or lower.
Not a fit: Patients with a history of cardiac arrhythmias, acute coronary syndrome, or contraindications to spinal anesthesia will not benefit from this study.
Why it matters
Potential benefit: If successful, this treatment could help reduce the risk of post-spinal hypotension in older patients, improving their surgical outcomes and recovery.
How similar studies have performed: While there is limited data on the specific use of dexamethasone for this purpose, similar studies have explored its effects in various contexts, indicating potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Patient undergoing orthopedic surgery in spinal anesthesia. ASA ≤ 2. Exclusion Criteria: Patients with history of cardiac arrhythmias. Patients with history of acute coronary syndrome. Patient with history of polytrauma. Patients with contraindication to SA (e.g., coagulopathy, thrombocytopenia, allergy to local anesthetic agent) and those on steroids or serotonin related medications (e.g., selective serotonin reuptake inhibitor) will be excluded.
Where this trial is running
Karachi, Sindh
- Shaheed Mohtarma Benazir Bhutto Institute of Trauma — Karachi, Sindh, Pakistan (Recruiting)
Study contacts
- Study coordinator: Sidra Javed, MBBS, FCPS, Pain fellow
- Email: sidra_dow@yahoo.com
- Phone: +92333 2474831
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.