Using Dexamethasone and Tranexamic Acid to Improve Recovery After Joint Replacement Surgery
Effectiveness of Peri-operative Combined Use of 2 Doses of Dexamethasone With Tranexamic Acid in Lower Limb Joint Replacements- A Randomized Controlled Trial.
This study is testing if giving two doses of dexamethasone along with tranexamic acid can help people recover better after hip or knee joint replacement surgery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 92 (estimated) |
| Ages | 45 Years and up |
| Sex | All |
| Sponsor | Indus Hospital and Health Network Academic / other |
| Locations | 1 site (Lahore, Punjab) |
| Trial ID | NCT06653699 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effectiveness of administering two doses of dexamethasone alongside tranexamic acid during lower limb joint replacement surgeries, such as hip and knee replacements. The study aims to assess the impact of this combination on postoperative outcomes, including levels of C-reactive protein (CRP), pain, fatigue, joint range of motion, and length of hospital stay. Participants will be randomly assigned to receive either one or two doses of dexamethasone, and their recovery will be monitored through questionnaires at various intervals post-surgery. The goal is to determine if this approach can enhance recovery and reduce complications.
Who should consider this trial
Good fit: Ideal candidates for this study are patients aged over 45 years scheduled for unilateral or bilateral total joint replacement surgery with a pre-operative hemoglobin level above 10g/dL.
Not a fit: Patients with a history of thromboembolic events, allergies to tranexamic acid or steroids, or pre-operative hemoglobin levels below 10g/dL may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved recovery times and reduced postoperative complications for patients undergoing joint replacement surgeries.
How similar studies have performed: Previous studies have shown positive outcomes with the use of dexamethasone and tranexamic acid in joint replacement surgeries, indicating potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients scheduled for unilateral or bilateral total joint replacement surgery in grade 4 osteoarthritis. * Patients having pre-operative hemoglobin above 10g/dL. * Include both genders. * Patients having age more than 45 years. Exclusion Criteria * Patients having history of thromboembolic event. * Patients having tranexamic and steroidal allergy. * Patients having pre operative Hemoglobin level less than 10g/dL * Patients having history of clotting disorders including abnormal prothrombin time, prothrombin time test, or international normalized ratio.
Where this trial is running
Lahore, Punjab
- Indus Hospital & Health Network — Lahore, Punjab, Pakistan (Recruiting)
Study contacts
- Principal investigator: Zaib Un Nisa, MS IN MSK PHYSIOTHERAPY — Indus Hospital and Health Network
- Study coordinator: Zaib Un Nisa, DPT, MS-MSK PHYSIOTHERAPY
- Email: zaibunnisa2226@gmail.com
- Phone: 201-357-5549
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.