Using Dexamethasone and N-acetylcysteine to prevent brain issues from carbon monoxide poisoning

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of combining Dexamethasone and N-acetylcysteine in preventing delayed neurocognitive sequelae (DNS) in patients who have suffered from carbon monoxide poisoning. It is a prospective pre-post intervention study that will enroll patients into treatment and control groups, with the primary outcome being the incidence of DNS within six weeks post-treatment. The hypothesis is based on previous studies suggesting that these medications may mitigate the oxidative stress and inflammation associated with DNS.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* History and clinical symptoms consistent with CO poisoning (initial blood carboxyhemoglobin (COHb) levels \>5%, or \>10% for smokers).

Exclusion Criteria:

* Concurrent use of other potentially lethal toxins. Severe trauma or burns that could be fatal. No spontaneous heartbeat or blood pressure before arrival. Poisoning time exceeding 24 hours before hospital arrival. Minors (under 18 years of age). Pregnant women. Patients or their families refuse to sign the consent form. Contraindications for the use of Dexamethasone or N-acetylcysteine (such as severe allergies) or when the physician assesses the risks outweigh the benefits.

Where it's running

• China Medical University Hospital
  Taichung, Taiwan Recruiting

Study contacts

• Study coordinator: Chi-Syuan Pan
• Email: miss321@gmail.com
• Phone: 0912697916

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.