Using denosumab to treat knee osteoarthritis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the effects of denosumab, a medication commonly used for osteoporosis, on patients suffering from knee osteoarthritis. The study aims to explore the potential of denosumab to inhibit the RANKL-RANK pathway, which is implicated in the progression of knee osteoarthritis. With a significant portion of the elderly population affected by this condition, the study seeks to provide insights into a possible effective treatment option that could alleviate symptoms and potentially reverse disease progression. Participants will be monitored for their response to the treatment over the course of the study.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* patients with knee osteoarthritis whose inclusion criteria meet the "diagnostic criteria for arthritis" .
* no drug contraindications .
* aged between 45 and 75 .
* committed to follow the research procedures, And cooperate with the •implementation of the whole process study .
* the patient understands the relevant treatment process .
* the patient has the ability to give informed consent .
* The patient had not recently taken any medication that affected observation.
* the subjects must meet all the inclusion criteria to be eligible to participate in the study .

Exclusion Criteria:

* mental illness .
* patients with malignant tumors.
* patients with other infectious diseases .
* patients with metabolic bone disease, diabetes and hyperthyroidism.
* patients who cannot actively cooperate in the treatment.
* hypocalcemia.

Where it's running

• Wuhan Union Hospital
  Wuhan, Hubei, China Recruiting

Study contacts

• Principal investigator: Tian Hongtao, Doctorate — Wuhan Union Medical College Hospital
• Study coordinator: Tian Hongtao, Doctorate
• Email: tianhongtao@vip.163.com
• Phone: 18627171618

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Preoperative Multimorbidity and Functional Recovery After Total Knee Arthroplasty

  This study tests whether higher burden of preoperative multimorbidity affects functional recovery after knee replacement in adults with knee osteoarthritis.

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• Cartilage biomarker response to acute loading in knee OA by antiresorptive treatment status

  Researchers will test whether a 30-minute treadmill walk changes cartilage biomarkers in postmenopausal women with knee osteoarthritis, comparing those on denosumab, bisphosphonates, and those not on antiresorptives.

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• Lysyl Enzymes in Knee Osteoarthritis

  This study tests whether blood levels of lysyl hydroxylase and lysyl oxidase differ between people with knee osteoarthritis and healthy individuals.

  Recruiting Afyonkarahisar Health Sciences University · Afyonkarahisar · NCT07875296

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.