Using deep learning to identify tumor origins from lymph node samples

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to develop a deep learning model that analyzes cytological images from lymph node punctures to predict the origins of tumors that have metastasized to lymph nodes. The model will be constructed using data collected from patients at West China Hospital and will be validated with a large test set to assess its performance. Additionally, the study will compare the accuracy of the deep learning model against human pathologists in diagnosing these cytology smears.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* From West China Hospital of Sichuan University (October 1, 2008-August 31, 2024) with corresponding clinical data, including age, sex, specimen puncture site, pathologic diagnosis, pathologic type, whether immunocytochemistry was added, clinical diagnosis, lesion site, co-morbidities, history of malignancy, treatment modality, occurrence of postoperative complications, total number of days of hospitalization postoperatively, and survival time;
* From the Department of Pathology of the First Affiliated Hospital of Zhengzhou University, the Sichuan Provincial Cancer Hospital, and the Cancer Hospital of the Chinese Academy of Medical Sciences (January 1, 2020-August 31, 2024) with corresponding clinical data, including age, sex, specimen puncture site, pathologic diagnosis, pathologic type, whether immunocytochemistry was added, clinical diagnosis, lesion site, co-morbidities, history of malignancy, treatment modality, occurrence of postoperative complications, total number of days of hospitalization postoperatively, and survival time.

Exclusion Criteria:

* Images lacking any supporting clinical or pathologic evidence to support a primary origin and its corresponding clinical information;
* Blank, poorly focused, and low-quality images containing severe artifacts and their corresponding clinical information.

Where it's running

• West China Hospital of Sichuan University
  Chengdu, Sichuan, China Recruiting

Study contacts

• Study coordinator: Jianyong Lei
• Email: guosiyin2000@163.com
• Phone: 02885423822

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Neoadjuvant Cryo-Thermal Ablation with Toripalimab and Chemo for Resectable NSCLC

  This study tests whether using Cryo-Thermal Ablation before chemo-immunotherapy helps people with resectable NSCLC see better outcomes.

  Recruiting Phase 2 West China Hospital · Chengdu, Sichuan and 8 other locations · NCT07855965

• Tai Chi during radiotherapy for head and neck cancer fatigue

  This trial tests whether a 12-week Yang-style Tai Chi program added to usual care can reduce cancer-related fatigue in adults with head and neck cancer undergoing radiotherapy.

  Recruiting West China Hospital · Chengdu, Sichuan · NCT07809776

• Wireless home prehabilitation for older adults with NSCLC awaiting lung surgery

  This study tests whether a personalized home exercise program guided by wearable devices can improve lung function for older NSCLC patients preparing for curative lung surgery.

  Recruiting West China Hospital · Chengdu, Sichuan · NCT07809763

• First-line combo therapy with GnP, SHR-1701, and Apatinib for metastatic pancreatic cancer

  This trial tests whether adding SHR-1701 and Apatinib to standard GnP can safely and effectively treat previously untreated metastatic pancreatic cancer.

  Recruiting Phase 1/2 West China Hospital · Chengdu, Sichuan · NCT07802184

• Early warning and stratified diagnosis of postoperative respiratory failure using ventilator waveform features

  This study tests whether patterns in ventilator waveforms can predict and categorize risk of breathing failure after surgery for adults on mechanical ventilation.

  Recruiting West China Hospital · Chengdu, Sichuan · NCT07799636

• JWK001 subretinal therapy for neovascular AMD

  This study tests a single subretinal dose of JWK001 at different levels in people with wet age-related macular degeneration who have previously responded to anti-VEGF treatment.

  Recruiting at 2 sites Phase 2 West China Hospital · Beijing, Beijing Municipality and 15 other locations · NCT07776522

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.