Using deep brain stimulation to treat Meige syndrome

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the safety and efficacy of combining bilateral single-electrode stimulation of the ventralis oralis nucleus with subthalamic nucleus deep brain stimulation in patients suffering from Meige syndrome, a rare movement disorder. Participants will be randomly assigned to one of two groups, and their motor symptoms will be assessed using the Burke-Fahn-Marsden Dystonia Rating Scale before and after treatment. Secondary outcomes will include quality of life and mental health assessments, as well as monitoring for any adverse effects related to the procedure. The findings aim to enhance treatment options for individuals with this debilitating condition.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Must meet the clinical diagnostic criteria for Meige syndrome
* Only includes patients with: Blepharospasm-type Meige syndrome and Blepharospasm with lower jaw muscle dystonia-type
* All patients must have undergone at least one year of systematic and standard treatment prior to surgery

Exclusion Criteria:

* History of neurological diseases other than Meige syndrome
* Severe cognitive impairment
* Severe psychiatric disorders

Where it's running

• Huashan Hospital, Fudan University.
  Shanghai, Shanghai Municipality, China Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.