Using deep brain stimulation to treat Meige syndrome
Evaluation of Bilateral Single-Electrode VO Combined With STN-DBS Stimulation in the Treatment of Meige Syndrome: A Prospective, Single-Center, Double-Blind, Randomized Controlled Exploratory Clinical Study
This study is testing a new deep brain stimulation method to see if it can help people with Meige syndrome improve their movement and overall quality of life.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Huashan Hospital Academic / other |
| Locations | 1 site (Shanghai, Shanghai Municipality) |
| Trial ID | NCT06912282 on ClinicalTrials.gov |
What this trial studies
This study evaluates the safety and efficacy of combining bilateral single-electrode stimulation of the ventralis oralis nucleus with subthalamic nucleus deep brain stimulation in patients suffering from Meige syndrome, a rare movement disorder. Participants will be randomly assigned to one of two groups, and their motor symptoms will be assessed using the Burke-Fahn-Marsden Dystonia Rating Scale before and after treatment. Secondary outcomes will include quality of life and mental health assessments, as well as monitoring for any adverse effects related to the procedure. The findings aim to enhance treatment options for individuals with this debilitating condition.
Who should consider this trial
Good fit: Ideal candidates are individuals diagnosed with blepharospasm-type Meige syndrome who have not responded adequately to standard treatments.
Not a fit: Patients with neurological diseases other than Meige syndrome or those with severe cognitive or psychiatric disorders may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly improve motor function and quality of life for patients with Meige syndrome.
How similar studies have performed: While deep brain stimulation has been explored for various dystonias, this specific dual-target approach is novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Must meet the clinical diagnostic criteria for Meige syndrome * Only includes patients with: Blepharospasm-type Meige syndrome and Blepharospasm with lower jaw muscle dystonia-type * All patients must have undergone at least one year of systematic and standard treatment prior to surgery Exclusion Criteria: * History of neurological diseases other than Meige syndrome * Severe cognitive impairment * Severe psychiatric disorders
Where this trial is running
Shanghai, Shanghai Municipality
- Huashan Hospital, Fudan University. — Shanghai, Shanghai Municipality, China (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.