Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Using D-dimer to improve patient discharge in emergency departments

Official title: Use of D-dimers in the Emergency Department to Identify Adult Patients at Very Low Risk of Mortality for Fast-track Treatment - a Randomized Controlled Study

Run by Odense University Hospital · NCT06219486 · Data updated 2026-11-12

This study tests if checking D-dimer levels can help doctors quickly identify low-risk patients in emergency departments who don't need to stay in the hospital.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment1538 (estimated)
SponsorOdense University Hospital
Academic / other
Locations2 sites (Esbjerg, Syd and 1 other locations)
StatusRecruiting
StartedJanuary 22, 2024
Main results expectedJuly 1, 2025
Study endsAugust 1, 2025
Registry record updatedApril 9, 2025
Trial IDNCT06219486 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults aged 18 and above who present with non-specific complaints and have stable vital signs.

Probably not a fit

Patients with unstable conditions requiring immediate care or those classified as triage level red will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the use of D-dimer levels to identify low-risk patients in emergency departments who may not require hospitalization. By conducting a multicenter randomized controlled trial, the researchers will assess whether providing D-dimer results influences the time to discharge disposition by physicians. The study focuses on patients with non-specific complaints who are stable upon arrival and have normal vital signs. The goal is to streamline patient care and reduce unnecessary hospital admissions.

Why it matters

Potential benefit: If successful, this approach could lead to faster discharge times and more efficient use of emergency department resources.

How similar studies have gone: Previous studies have indicated that normal D-dimer levels correlate with low risk of significant disease, suggesting potential success for this approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age 18 or above
* Able to provide oral and written informed consent in Danish
* Blood tests ordered on arrival as part of standard of care
* Ambulatory on arrival or walking to the ambulance (i.e., stable independent gait)
* Normal vital signs (i.e., National Early Warning Score \< 3)

Exclusion Criteria:

* Unstable condition requiring immediate care in the resuscitation area
* Triage level red (i.e., the most urgent patients)
* Trauma (minor and major) patients
* High likelihood of requiring a D-dimer analysis on clinical indications during the current hospital contact (e.g., suspected venous thromboembolic disease) that will be ordered on arrival regardless of this study
* Previous participation in the study

Where it's running

  • Esbjerg Hospital
    Esbjerg, Syd, Denmark
    Recruiting
  • Odense University Hospital
    Odense, Syd, Denmark
    Not yet recruiting

Study contacts

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.