Using D-dimer to improve patient discharge in emergency departments
Official title: Use of D-dimers in the Emergency Department to Identify Adult Patients at Very Low Risk of Mortality for Fast-track Treatment - a Randomized Controlled Study
Run by Odense University Hospital · NCT06219486 · Data updated 2026-11-12
This study tests if checking D-dimer levels can help doctors quickly identify low-risk patients in emergency departments who don't need to stay in the hospital.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 1538 (estimated) |
| Sponsor | Odense University Hospital Academic / other |
| Locations | 2 sites (Esbjerg, Syd and 1 other locations) |
| Status | Recruiting |
| Started | January 22, 2024 |
| Main results expected | July 1, 2025 |
| Study ends | August 1, 2025 |
| Registry record updated | April 9, 2025 |
| Trial ID | NCT06219486 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and above who present with non-specific complaints and have stable vital signs.
✕Probably not a fit
Patients with unstable conditions requiring immediate care or those classified as triage level red will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to evaluate the use of D-dimer levels to identify low-risk patients in emergency departments who may not require hospitalization. By conducting a multicenter randomized controlled trial, the researchers will assess whether providing D-dimer results influences the time to discharge disposition by physicians. The study focuses on patients with non-specific complaints who are stable upon arrival and have normal vital signs. The goal is to streamline patient care and reduce unnecessary hospital admissions.
Why it matters
Potential benefit: If successful, this approach could lead to faster discharge times and more efficient use of emergency department resources.
How similar studies have gone: Previous studies have indicated that normal D-dimer levels correlate with low risk of significant disease, suggesting potential success for this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 or above * Able to provide oral and written informed consent in Danish * Blood tests ordered on arrival as part of standard of care * Ambulatory on arrival or walking to the ambulance (i.e., stable independent gait) * Normal vital signs (i.e., National Early Warning Score \< 3) Exclusion Criteria: * Unstable condition requiring immediate care in the resuscitation area * Triage level red (i.e., the most urgent patients) * Trauma (minor and major) patients * High likelihood of requiring a D-dimer analysis on clinical indications during the current hospital contact (e.g., suspected venous thromboembolic disease) that will be ordered on arrival regardless of this study * Previous participation in the study
Where it's running
-
Esbjerg Hospital
Esbjerg, Syd, Denmark Recruiting -
Odense University Hospital
Odense, Syd, Denmark Not yet recruiting
Study contacts
- Study coordinator: Mette Løkke, RN
- Email: mette.loekke@rsyd.dk
- Phone: 4551730068
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.