Using curcumin to prevent vocal cord adhesions after surgery

Clinical Study of Curcumin in Preventing Postoperative Adhesion of Bilateral Vocal Cords

This study tests if using curcumin after vocal cord surgery can help prevent complications like adhesions better than standard treatments.

Quick facts

• Phase: PHASE1; PHASE2
• Study type: Interventional
• Enrollment: 100 (estimated)
• Ages: 18 Years to 75 Years
• Sex: All
• Sponsor: Eye & ENT Hospital of Fudan University (other)
• Locations: 1 site (Shanghai, Shanghai Municipality)
• Trial ID: NCT05688488 on ClinicalTrials.gov

What this trial studies

This clinical study investigates the application of curcumin to prevent postoperative adhesion of bilateral vocal cords in patients undergoing endoscopic resection of vocal cord lesions. Participants will receive curcumin treatment on the wound sites following their surgical procedures. The study aims to evaluate the effectiveness of curcumin compared to standard treatments like Mitomycin-C in reducing complications associated with vocal cord surgeries.

Who should consider this trial

Good fit: Ideal candidates include patients with bilateral vocal cord diseases scheduled for endoscopic resection or incision of vocal cord adhesions.

Not a fit: Patients with other laryngeal diseases or those with significant cardiac and pulmonary insufficiencies may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could significantly reduce the incidence of postoperative adhesions, improving recovery and vocal function for patients.

How similar studies have performed: While the use of curcumin in this specific context is novel, similar studies exploring its therapeutic effects in other surgical settings have shown promising results.

Eligibility criteria

Inclusion Criteria:

1. Patients with bilateral vocal cord diseases who are going to undergo resection of bilateral vocal cord lesions endoscopically.
2. Patients with bilateral vocal cord adhesion who are going to undergo incision of bilateral vocal cord adhesion endoscopically.

Exclusion Criteria:

1. Patients with other laryngeal diseases.
2. Patients with cardiac and pulmonary insufficiency.
3. Patients unable to cooperate with the follow-up on time after surgery.
4. Patients who refuse to sign the informed consent after notification.
5. Patients who have a severe allergic disease or allergic history to a variety of drugs.
6. Other circumstances that are not appropriate to be included in the clinical trial.

Where this trial is running

Shanghai, Shanghai Municipality

• Eye & ENT Hospital of Fudan University — Shanghai, Shanghai Municipality, China (RECRUITING)

Study contacts

• Study coordinator: Jian Chen, Ph.D

Conditions: Glottic Web of Larynx, Laryngeal Stenosis, Glottic Carcinoma, Laryngeal Leucoplakia, Laryngeal Polyp, Laryngeal Papilloma, Curcumin