Using curcumin to prevent vocal cord adhesions after surgery
Official title: Clinical Study of Curcumin in Preventing Postoperative Adhesion of Bilateral Vocal Cords
Run by Eye & ENT Hospital of Fudan University · NCT05688488 · Data updated 2026-11-12
This study tests if using curcumin after vocal cord surgery can help prevent complications like adhesions better than standard treatments.
Quick facts
| Phase | Phase1; Phase2 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Eye & ENT Hospital of Fudan University Academic / other |
| Locations | 1 site (Shanghai, Shanghai Municipality) |
| Status | Recruiting |
| Started | May 5, 2023 |
| Main results expected | December 31, 2025 |
| Study ends | December 31, 2026 |
| Registry record updated | May 6, 2023 |
| Trial ID | NCT05688488 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include patients with bilateral vocal cord diseases scheduled for endoscopic resection or incision of vocal cord adhesions.
✕Probably not a fit
Patients with other laryngeal diseases or those with significant cardiac and pulmonary insufficiencies may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical study investigates the application of curcumin to prevent postoperative adhesion of bilateral vocal cords in patients undergoing endoscopic resection of vocal cord lesions. Participants will receive curcumin treatment on the wound sites following their surgical procedures. The study aims to evaluate the effectiveness of curcumin compared to standard treatments like Mitomycin-C in reducing complications associated with vocal cord surgeries.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the incidence of postoperative adhesions, improving recovery and vocal function for patients.
How similar studies have gone: While the use of curcumin in this specific context is novel, similar studies exploring its therapeutic effects in other surgical settings have shown promising results.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients with bilateral vocal cord diseases who are going to undergo resection of bilateral vocal cord lesions endoscopically. 2. Patients with bilateral vocal cord adhesion who are going to undergo incision of bilateral vocal cord adhesion endoscopically. Exclusion Criteria: 1. Patients with other laryngeal diseases. 2. Patients with cardiac and pulmonary insufficiency. 3. Patients unable to cooperate with the follow-up on time after surgery. 4. Patients who refuse to sign the informed consent after notification. 5. Patients who have a severe allergic disease or allergic history to a variety of drugs. 6. Other circumstances that are not appropriate to be included in the clinical trial.
Where it's running
-
Eye & ENT Hospital of Fudan University
Shanghai, Shanghai Municipality, China Recruiting
Study contacts
- Study coordinator: Jian Chen, Ph.D
- Email: chenjent@qq.com
- Phone: +8621-64377134
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.