Using CT scans to improve coronary artery examinations
Coronary Computed Tomography Angiography For Optimized Invasive Coronary examInation
This study tests if using CT scans during heart exams can make the process safer and quicker for people with stable angina.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 120 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Aarhus University Hospital Skejby Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Aarhus N, Central Region) |
| Trial ID | NCT05218694 on ClinicalTrials.gov |
What this trial studies
This trial evaluates the effectiveness of integrating coronary computed tomography angiography (CCTA) information into invasive coronary examinations for patients with stable angina pectoris. A total of 120 patients will be randomized into two groups: one receiving standard treatment and the other utilizing a CT-guided algorithm for a more focused examination. The primary goals are to reduce patient radiation exposure, procedure time, and the use of procedural utensils and contrast. The study aims to determine if a more targeted approach can enhance the efficiency and safety of coronary interventions.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 81 with stable angina and at least one coronary artery with significant stenosis.
Not a fit: Patients with significant bleeding risks, known pregnancy, or chronic total occlusion may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to safer and more efficient coronary interventions for patients with ischemic heart disease.
How similar studies have performed: Other studies have shown promise in using imaging techniques to guide interventions, suggesting potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age \> 18 and \< 81 years * Stable angina * at least 1 vessel disease in either the left coronary artery or right coronary artery * Stenosis grater than 50% and no stenosis greater than 40% on contralateral vessel unless fractional flow reserve by CT (FFRct) \>0.80 * Vessel segment \> 2 mm in diameter * Subject eligible for Dual Anti Platelet Therapy (DAPT Exclusion Criteria: * Significant bleeding risk or other contraindications against heparinization or DAPT * Known pregnancy * Life expectancy \< 120 days * Patient unable to provide informed consent * Patients with CTO (Chronic Total Occlusion).
Where this trial is running
Aarhus N, Central Region
- Aarhus University Hospital, Depart. of Cardiology — Aarhus N, Central Region, Denmark (Recruiting)
Study contacts
- Study coordinator: Nicolaj B Støttrup, MD, PH.D
- Email: nicostoe@rm.dk
- Phone: +45 78450000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.