Using creatine to help treat depression in methamphetamine users

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effects of creatine monohydrate on depression and anxiety in male and female individuals who are dependent on methamphetamine. It aims to determine whether creatine can alleviate depressive symptoms and reduce methamphetamine use while also assessing its safety in this population. Participants must have a current diagnosis of methamphetamine dependence, major depressive disorder, and an anxiety disorder, with specific severity scores on standardized scales. The study will monitor the participants' responses to creatine over a defined treatment period.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Current primary diagnosis of methamphetamine dependence or abuse, with methamphetamine preferred drug of abuse
* Current diagnosis of major depressive disorder (primary or substance-induced)
* Current diagnosis of an anxiety disorder (primary or substance-induced)
* Current Hamilton Depression Rating scale score \> or = to 16
* Current Hamilton Anxiety Scale score \> = to 18
* If taking a psychotropic medication for depressed or anxious mood, regimen must be stable for \> = to 4 weeks prior to creatine treatment initiation

Exclusion Criteria:

* Persons unable to provide adequate informed consent
* Persons who are at clinically significant suicidal or homicidal risk
* Primary substance-related diagnosis other than methamphetamine dependence or abuse
* Positive pregnancy test (females only)
* History of renal disease
* Clinically significant medical or neurological illness identified by history, physical exam and laboratory testing
* History of hypersensitivity reaction to creatine

Where it's running

• Montana State University College of Nursing (Missoula campus)
  Missoula, Montana, United States Recruiting

Study contacts

• Principal investigator: Tracy Hellem, PhD — Montana State University
• Study coordinator: Tracy Hellem, PhD
• Email: tracy.hellem1@montana.edu
• Phone: 406 243 2110

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.