Using CPX-351 to prevent relapse in patients with Acute Myeloid Leukemia in remission

Phase IB/II of CPX-351 as Maintenance Therapy in AML Patients Ineligible for Bone Marrow Transplantation

This study tests if a new treatment called CPX-351 can help people with Acute Myeloid Leukemia who are in remission stay cancer-free longer.

Quick facts

• Phase: Phase1; Phase2
• Study type: Interventional
• Enrollment: 24 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Georgetown University (Academic / other)
• Drugs / interventions: doxorubicin
• Locations: 3 sites (Washington D.C., District of Columbia and 2 other locations)
• Trial ID: NCT04990102 on ClinicalTrials.gov

What this trial studies

This phase IB/II study evaluates the effectiveness of CPX-351 in preventing relapse in patients with Acute Myeloid Leukemia (AML) who are in complete remission. The study employs a 3+3 dose de-escalation design, where patients will receive maintenance treatment for six cycles, with doses adjusted based on toxicity. The maximum tolerated dose identified in phase IB will be used for the phase II expansion, allowing for a thorough assessment of safety and efficacy.

Who should consider this trial

Good fit: Ideal candidates include adults over 18 years old with newly diagnosed AML in complete remission who are ineligible for allogeneic bone marrow transplant.

Not a fit: Patients who are not in remission or those with M3 AML will not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could significantly reduce the risk of relapse in AML patients who are currently in remission.

How similar studies have performed: Other studies have shown promise with similar approaches in AML treatment, indicating a potential for success.

Eligibility criteria

Inclusion Criteria:

* Newly diagnosed patients \> 18 years of age
* Patients must be in CR or CRh (complete remission with partial count recovery).
* Must have received ANY induction treatment with standard consolidation or hypomethylating agent (HMA) + venetoclax, for up to 6 cycles or no more than 12 cycles of treatment.
* Must be able to start therapy within 3 months of last documented CR
* De novo or secondary AML/treatment related AML (non-M3) including AML with myelodysplasia-related changes (MRC), histologically confirmed
* Patients must be ineligible for allogeneic BMT (for any reason including poor performance status, patient's preference, favorable AML not a candidate for transplant, or comorbidities and age precluding from transplant etc)
* Cardiac ejection fraction ≥ 50% by transthoracic echocardiography or MUGA scan
* Adequate hepatic and renal function defined as:

  * Serum aspartate transaminase (AST) or alanine transaminase (ALT) ≤ 3 x upper limit of normal (ULN)
  * Serum aspartate transaminase (AST) or alanine transaminase (ALT) ≤ 3 is permissible if due to disease.
  * Bilirubin ≤3 x ULN (unless bilirubin rise is due to Gilbert's syndrome or of non-hepatic origin)
  * Estimated Creatinine Clearance ≥30 ml/min (Cockcroft-Gault based on actual weight) (See Appendix A)
* Eastern Cooperative Oncology Group (ECOG) performance status of ≤ 3 (Appendix A)
* Female subjects who are of non-reproductive potential (i.e., post-menopausal by history - no menses for ≥1 year; OR history of hysterectomy; OR history of bilateral tubal ligation; OR history of bilateral oophorectomy). Female subjects of childbearing potential must have a negative serum pregnancy test upon study entry.
* Male and female subjects who agree to use highly effective methods of birth control (e.g., condoms, implants, injectables, combined oral contraceptives, some intrauterine devices \[IUDs\], sexual abstinence, or sterilized partner) during the period of therapy and for at least 6 months after the last dose of study drug

Exclusion Criteria:

* Prior allogeneic transplant
* Previous cumulative anthracycline (doxorubicin equivalent) dose equal to or greater than 345 mg/m2, and for patients with prior mediastinal XRT, anthracycline dose equal to or greater than 295 mg/m2
* Acute promyelocytic leukemia \[t(15;17)\]
* If patient is unable to sign informed consent due to any serious medical condition, laboratory abnormality or psychiatric illness
* Patients with evidence of uncontrolled current myocardial impairment (e.g. unstable ischemic heart disease, uncontrolled arrhythmia, symptomatic valvular dysfunction not controlled on medical therapy, uncontrolled hypertensive heart disease, and uncontrolled congestive heart failure)
* History of Wilson's disease or other copper-related disorders
* History of allergic reactions attributed to compounds of similar composition to cytarabine and daunorubicin or liposomal products
* History of other malignancies, except:

  * Malignancy treated with curative intent and with no known active disease present for ≥ 3 years before the first dose of study drug and felt to be at low risk for recurrence by treating physician.
  * Adequately treated non-melanoma skin cancer or lentigo maligna without evidence of disease.
  * Adequately treated low risk prostate cancer or carcinoma in situ without evidence of disease.
* Unresolved toxicities from prior anti-cancer therapy, defined as having not resolved to Common Terminology Criteria for Adverse Event (CTCAE, version 4.03), grade ≤1, or to the levels dictated in the inclusion/exclusion criteria with the exception of alopecia.
* Known bleeding disorders (e.g., von Willebrand's disease) or hemophilia
* Known active infection with hepatitis C virus (HCV) or hepatitis B virus (HBV).
* Subjects who are positive for hepatitis B core antibody, hepatitis B surface antigen, hepatitis C antibody, must have a negative polymerase chain reaction (PCR) result for the respective disease before enrollment. Those who are PCR positive will be excluded.
* Any uncontrolled active systemic infection.
* Any life-threatening illness, medical condition, or organ system dysfunction that, in the investigator's opinion, could compromise the subject's safety or put the study outcomes at undue risk.
* Currently active, clinically significant cardiovascular disease, such as uncontrolled arrhythmia or Class 3 or 4 congestive heart failure as defined by the New York Heart Association Functional Classification; or a history of myocardial infarction, unstable angina, or acute coronary syndrome within 6 months prior to randomization.
* Known CNS involvement by leukemia
* Erythema multiforme, toxic epidermal necrolysis, or Stevens-Johnson syndrome
* Lactating or pregnant.
* Unwilling or unable to participate in all required study evaluations and procedures.
* Unable to understand the purpose and risks of the study and to provide a signed and dated informed consent form (ICF) and authorization to use protected health information (in accordance with national and local subject privacy regulations).
* Currently active, clinically significant hepatic impairment (≥ moderate hepatic impairment according to the Child Pugh classification (class B or C))

Where this trial is running

Washington D.C., District of Columbia and 2 other locations

• Georgetown Lombardi Comprehensive Cancer Center — Washington D.C., District of Columbia, United States (Recruiting)
• John Theurer Cancer Center at Hackensack University Medical Center — Hackensack, New Jersey, United States (Recruiting)
• University of Pennsylvania — Philadelphia, Pennsylvania, United States (Recruiting)

Study contacts

• Principal investigator: Kimberley Doucette, MD — Georgetown University

Conditions Acute Myeloid Leukemia in Remission; Acute Myeloid Leukemia; Remission