Using COX-2 inhibitors to prevent urethral stricture recurrence after surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness and safety of COX-2 inhibitors, specifically meloxicam, in reducing the recurrence of urethral strictures following direct vision internal urethrotomy. It focuses on patients with idiopathic or iatrogenic urethral strictures and aims to determine if administering NSAIDs can lead to better long-term outcomes. The study will compare outcomes between those receiving the medication and those given a placebo. Participants will be monitored for stricture recurrence over a specified follow-up period.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years
* American Society of Anesthesiologists (ASA) score ≤3.
* Urethral stricture length ≤ 1.5 cm

Exclusion Criteria:

* Recurrent urethral stricture ≥ 2 times.
* Pelvic fracture urethral distraction defect (PFUDD).

Where it's running

• New Valley University
  New Valley, New Valley Governorate, Egypt Recruiting

Study contacts

• Study coordinator: Waheed F Abdelrasol, MD
• Email: waheed_fawzy@med.nvu.edu.eg
• Phone: 00201207722518

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Thrombocytopenia Trajectories in antiphospholipid syndrome

  This study tests whether patterns in platelet counts over time can predict outcomes for adults with antiphospholipid syndrome.

  Recruiting New Valley University · Al Khārjah, Kharga Oasis · NCT07757789

• AIHA in antiphospholipid syndrome: what it means for APS patients

  This study tests how autoimmune hemolytic anemia affects people with antiphospholipid syndrome and what it means for their risk of clots and organ problems.

  Recruiting New Valley University · Al Khārjah, Kharga Oasis · NCT07743242

• Hematological Markers MPV, PLR, and NLR in Primary Versus Secondary APS

  This study tests whether blood markers MPV, PLR, and NLR differ between people with primary antiphospholipid syndrome and those with APS secondary to another autoimmune disease.

  Recruiting New Valley University · Al Khārjah, Kharga Oasis · NCT07142239

• Comparing Dexmedetomidine and Ketamine for Inflammatory Response in Sepsis Patients

  This study is testing whether Dexmedetomidine or Ketamine works better to help reduce inflammation and improve blood flow in adults recovering from surgery for severe abdominal infections.

  Recruiting Phase 1/2 New Valley University · Asyut · NCT06490731

• Pain management using a retroclavicular block for vascular surgery

  This study is testing a new way to manage pain during upper limb vascular surgery to see if it helps patients feel better and recover faster, especially when combined with a medication called dexamethasone.

  Recruiting New Valley University · Asyut · NCT06406712

• Pain management using a nerve block for upper limb surgery

  This study tests if a new type of nerve block can help manage pain better during upper limb surgeries and improve patient satisfaction.

  Recruiting New Valley University · Asyut · NCT06406647

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.