Using coronary CTA to improve heart disease prevention in asymptomatic Chinese adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate whether a coronary computed tomography angiography (CCTA)-based strategy for preventing coronary heart disease (CHD) is more effective than traditional risk score methods in managing lipid levels and cardiovascular risk factors. It will involve 3,400 asymptomatic participants aged 40 to 69 from Nanjing, who will be randomly assigned to receive either CCTA-guided or traditional risk score-guided prevention programs. The effectiveness of these strategies will be assessed after 12 months, focusing on lipid-lowering treatment and control of cardiovascular risk factors. Additionally, the study will provide insights into the prevalence of subclinical coronary atherosclerosis in this population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Nanjing residents who have no plans to leave in the next 5 years
2. Aged from 40 to 69 years
3. Free of any known clinically cardiovascular disease Able to comprehend and sign an informed consent form

Exclusion Criteria:

1. Serious liver dysfunction, defined as AST or ALT \> 3 times the normal upper limit
2. Chronic kidney disease (CKD) \> stage 4, defined as eGFR \< 30 ml/min/1.73 m2
3. Prior CCTA or invasive coronary angiography within the last 5 years
4. Any contraindications for CCTA
5. Previous use of statin or non-statin lipid-lowering medication (such as ezetimibe, PCSK9 inhibitor and XueZhiKang)
6. Life expectancy \< 3 years
7. Other reasons the researcher deems inappropriate to attend

Where it's running

• Research Institute Of Medical Imaging Jinling Hospital
  Nanjing, Jiangsu, China Recruiting

Study contacts

• Study coordinator: Longjiang Zhang, MD
• Email: kevinzhlj@163.com
• Phone: 13405833167

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.