Clinical trial Recruiting at 1 site Observational Ages 18 and up

Using contrast-enhanced ultrasound to better understand unclear liver lesions

Official title: The Role of Contrast Enhanced Ultrasond (Ceus), in the Characterization of Focal Liver Lesions Indeterminate to Second-level Methods

Run by IRCCS Azienda Ospedaliero-Universitaria di Bologna · NCT06876805 · Data updated 2026-11-12

This study is testing if a special type of ultrasound can help doctors better understand unclear liver spots that other scans couldn't clearly identify.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment100 (estimated)
SponsorIRCCS Azienda Ospedaliero-Universitaria di Bologna
Academic / other
Locations1 site (Bologna)
StatusRecruiting
StartedAugust 1, 2024
Main results expectedAugust 1, 2026
Study endsApril 1, 2027
Registry record updatedMarch 14, 2025
Trial IDNCT06876805 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults aged 18 and older who have had inconclusive imaging results for liver lesions and have undergone CEUS in the last six months.

Probably not a fit

Patients who cannot undergo ultrasound evaluation due to technical limitations or have allergies to the ultrasound contrast medium may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the effectiveness of contrast-enhanced ultrasound (CEUS) in accurately characterizing focal liver lesions that have been inconclusive through CT, MRI, or PET scans. It will involve both retrospective and prospective data collection, with a follow-up period of six months to assess outcomes based on the gold standard reference. The study will include patients who have undergone CEUS within the last six months and will analyze the results to determine whether the lesions are benign or malignant.

Why it matters

Potential benefit: If successful, this study could improve diagnostic accuracy for patients with uncertain liver lesions, leading to better treatment decisions.

How similar studies have gone: Other studies have shown promise in using CEUS for liver lesion characterization, suggesting that this approach may be effective.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age ≥18 years.
* CEUS performed performed in the last 6 months a CT, MRI and/or PET not decisive in characterizing a liver lesion.
* Obtaining informed consent.

Exclusion Criteria:

* Technical impossibility to perform the ultrasound evaluation.
* Documented allergy to the ultrasound contrast medium.

Where it's running

  • Policlinico Sant'Orsola Malpighi
    Bologna, Italy
    Recruiting

Study contacts

  • Principal investigator: Carla Serra, PhD — IRCCS Azienda Ospedaliero-Universitaria di Bologna
  • Study coordinator: Carla Serra, PhD
  • Email: carla.serra@aosp.bo.it
  • Phone: +390512143270

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.