Using contrast-enhanced ultrasound to better understand unclear liver lesions
Official title: The Role of Contrast Enhanced Ultrasond (Ceus), in the Characterization of Focal Liver Lesions Indeterminate to Second-level Methods
Run by IRCCS Azienda Ospedaliero-Universitaria di Bologna · NCT06876805 · Data updated 2026-11-12
This study is testing if a special type of ultrasound can help doctors better understand unclear liver spots that other scans couldn't clearly identify.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | IRCCS Azienda Ospedaliero-Universitaria di Bologna Academic / other |
| Locations | 1 site (Bologna) |
| Status | Recruiting |
| Started | August 1, 2024 |
| Main results expected | August 1, 2026 |
| Study ends | April 1, 2027 |
| Registry record updated | March 14, 2025 |
| Trial ID | NCT06876805 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older who have had inconclusive imaging results for liver lesions and have undergone CEUS in the last six months.
✕Probably not a fit
Patients who cannot undergo ultrasound evaluation due to technical limitations or have allergies to the ultrasound contrast medium may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to evaluate the effectiveness of contrast-enhanced ultrasound (CEUS) in accurately characterizing focal liver lesions that have been inconclusive through CT, MRI, or PET scans. It will involve both retrospective and prospective data collection, with a follow-up period of six months to assess outcomes based on the gold standard reference. The study will include patients who have undergone CEUS within the last six months and will analyze the results to determine whether the lesions are benign or malignant.
Why it matters
Potential benefit: If successful, this study could improve diagnostic accuracy for patients with uncertain liver lesions, leading to better treatment decisions.
How similar studies have gone: Other studies have shown promise in using CEUS for liver lesion characterization, suggesting that this approach may be effective.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥18 years. * CEUS performed performed in the last 6 months a CT, MRI and/or PET not decisive in characterizing a liver lesion. * Obtaining informed consent. Exclusion Criteria: * Technical impossibility to perform the ultrasound evaluation. * Documented allergy to the ultrasound contrast medium.
Where it's running
-
Policlinico Sant'Orsola Malpighi
Bologna, Italy Recruiting
Study contacts
- Principal investigator: Carla Serra, PhD — IRCCS Azienda Ospedaliero-Universitaria di Bologna
- Study coordinator: Carla Serra, PhD
- Email: carla.serra@aosp.bo.it
- Phone: +390512143270
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.