Using contrast echocardiography during exercise to assess pulmonary blood volume
Assessment of Pulmonary Blood Volume Using Contrast Echocardiography During Exercise
This study is testing if a special heart ultrasound can safely measure blood volume in the lungs during exercise to help understand how it affects people with and without heart failure.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 800 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Mayo Clinic Academic / other |
| Locations | 1 site (Rochester, Minnesota) |
| Trial ID | NCT06195059 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the effectiveness of pulmonary blood volume (PBV) measurements obtained through contrast echocardiography as a non-invasive alternative to invasive pulmonary artery wedge pressure (PAWP) during exercise. It will compare changes in PBV in patients with and without heart failure and pulmonary vascular disease. The study will involve patients referred for invasive exercise right heart catheterization due to exertional dyspnea, allowing for a comprehensive assessment of PBV in relation to exercise performance.
Who should consider this trial
Good fit: Ideal candidates include patients referred for invasive exercise right heart catheterization who experience exertional dyspnea and have varying degrees of pulmonary hypertension.
Not a fit: Patients who are unable or unwilling to undergo echocardiography or have had prior adverse reactions to echo contrast administration may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a safer, non-invasive method for assessing pulmonary blood volume in patients with heart failure and pulmonary vascular disease.
How similar studies have performed: While this approach is innovative, it builds on existing methodologies in echocardiography, and similar studies have shown promise in non-invasive assessments of cardiac function.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients referred to the cardiac catheterization laboratory for invasive exercise right heart catheterization for evaluating exertional dyspnea. Investigators will include patients with normal or low EF, and across the spectrum of pulmonary hypertension severity. Exclusion Criteria: * Patient inability or unwillingness to undergo echocardiography including a contrast method, or if echocardiography would, in the opinion of the investigator, somehow compromise the quality of data acquisition for the clinical case. * Prior adverse reaction to echo contrast administration
Where this trial is running
Rochester, Minnesota
- Mayo Clinic in Rochester — Rochester, Minnesota, United States (Recruiting)
Study contacts
- Principal investigator: Barry Borlaug, MD — Mayo Clinic
- Study coordinator: Circulatory Failure Research Team
- Phone: 507-255-2200
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.