Using concentrated growth factors to preserve tooth extraction sites
Study on the Effect of Concentrated Growth Factor in Promoting the Regeneration and Preservation of Soft and Hard Tissues
This study tests if using concentrated growth factors during tooth extraction can help patients heal better and preserve the area for future dental work.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 25 Years to 45 Years |
| Sex | All |
| Sponsor | The Fourth Affiliated Hospital of Zhejiang University School of Medicine Academic / other |
| Locations | 1 site (Yiwu, Zhejiang Procince) |
| Trial ID | NCT06308536 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effectiveness of concentrated growth factors (CGF) in preserving and regenerating soft and hard tissues during tooth extraction site preservation surgery. A total of 20 patients will be randomly assigned to four different treatment groups, each receiving various combinations of bone powder, collagen membranes, and CGF. The study aims to evaluate outcomes such as pain levels, wound healing, and changes in gingival and alveolar dimensions over a follow-up period of more than six months. The same physician will perform all surgeries to ensure consistency in the procedure.
Who should consider this trial
Good fit: Ideal candidates are healthy adults aged 25 to 45 who require tooth extraction and are willing to undergo site preservation without systemic diseases affecting healing.
Not a fit: Patients with serious systemic diseases like diabetes or hypertension, or those outside the age range of 25 to 45, may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could enhance healing and tissue preservation after tooth extractions, leading to better long-term dental outcomes.
How similar studies have performed: While the use of CGF in dental procedures is gaining interest, this specific application in extraction site preservation is relatively novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Voluntarily participate in this trial and sign a written informed consent; Patients aged 25 ≤ age ≤ 45 years; The combination of intraoral and imaging examinations confirms that the affected tooth has no preservation value, requires tooth extraction, and the patient is willing to use site preservation; No progressive periodontal disease or acute apical periodontitis in the affected teeth; No long-term history of oral bisphosphonates; Non smoking patients； No systemic diseases such as diabetes and hypertension. Exclusion Criteria: Patients who have difficulty tolerating surgery; Patients under 25 years old or above 45 years old; The whole body is accompanied by hypertension, diabetes and other serious systemic diseases, which need to be controlled by drugs; Patients who take oral medication that affects bone metabolism for at least one month due to the need for disease treatment; Patients who take medication that may affect platelet function was used within 3 months due to the need for disease treatment; Patients unable to undergo X-ray imaging examination due to pregnancy or preparation after site preservation surgery; Patients who Smoke; The apical and periodontal inflammation is in the acute phase (purulent phase) Regular follow-up or follow-up for more than 6 months is not allowed
Where this trial is running
Yiwu, Zhejiang Procince
- The Fourth Affiliated Hospital Zhejiang University School of Medicine — Yiwu, Zhejiang Procince, China (Recruiting)
Study contacts
- Study coordinator: Genying Zhuang, Master
- Email: 20918620@zju.edu.cn
- Phone: 13758195143
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.