Using compression ultrasound to rule out deep vein thrombosis in low-risk patients
Official title: Evaluation of the Predictive Value of Compression Venous Ultrasound by the Emergency Physician for Excluding the Diagnosis of Proximal Deep Vein Thrombosis (DVT) in Patients With Non-high Clinical Pretest Probability
Run by University Hospital, Strasbourg, France · NCT04917328 · Data updated 2026-11-12
This study tests if using compression ultrasound can help doctors rule out deep vein thrombosis in low-risk patients who show symptoms when they come to the emergency room.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 700 (estimated) |
| Sponsor | University Hospital, Strasbourg, France Academic / other |
| Locations | 1 site (Strasbourg) |
| Status | Recruiting |
| Started | February 21, 2022 |
| Main results expected | February 28, 2027 |
| Study ends | February 28, 2028 |
| Registry record updated | August 19, 2026 |
| Trial ID | NCT04917328 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults presenting to the emergency department with clinical suspicion of DVT and a low probability score.
✕Probably not a fit
Patients with a high probability of DVT or those with suspected pulmonary embolism will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effectiveness of compression ultrasound as a diagnostic tool for ruling out deep vein thrombosis (DVT) in patients with a low probability of the condition, as determined by the modified Wells score. The researchers hypothesize that compression ultrasound can provide accurate results comparable to the standard D-dimer assay. Adult patients presenting to the emergency department with symptoms suggestive of DVT will be included if they meet specific criteria. The study aims to improve diagnostic accuracy and patient care in emergency settings.
Why it matters
Potential benefit: If successful, this approach could streamline the diagnostic process for DVT, reducing unnecessary tests and improving patient outcomes.
How similar studies have gone: While compression ultrasound is commonly used, this specific approach in low-risk patients is less established, making it a novel investigation.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * adult patient * Patient presenting to the emergency department with clinical suspicion of DVT (i.e. pain and/or lower extremity edema). * Patient with a non-high probability according to the modified Wells score, i.e. a score of 0 or 1 * Subject with a social health insurance plan * Subject able to understand the objectives and risks of the research and to give a signed and dated informed consent Exclusion Criteria: * Patient with suspected pulmonary embolism * Patient with a high probability of DVT * Impossible to perform a whole leg doppler ultrasound within 5 days * Pregnant or breast-feeding woman, on patient's declaration * Subject under court protection * Subject under guardianship or curatorship
Where it's running
-
CHU Strasbourg
Strasbourg, France Recruiting
Study contacts
- Study coordinator: Pierrick LE BORGNE, MD
- Email: pierrick.leborgne@chru-strasbourg.fr
- Phone: 03.88.12.86.90
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
TRiP-cast score test in adults with acute lower-limb injuries requiring immobilization
This study tests whether the TRiP(cast) score can predict risk of blood clots in adults with acute lower-limb injuries treated as outpatients.
-
Comparing ClotTriever vs. aspiration thrombectomy for acute iliofemoral DVT
This study tests whether the ClotTriever System clears clot better than aspiration thrombectomy in adults with acute iliofemoral deep vein thrombosis.
-
Profunda Femoris Vein Thrombosis Clearance to Improve Outcomes of Endovascular Treatment
This trial tests whether clearing a blockage in the profunda femoris vein during endovascular treatment helps keep the iliofemoral vein open and reduces post-thrombotic syndrome in adults with acute iliofemoral DVT.
-
Collecting ultrasound images to improve DVT detection
This study is collecting ultrasound images from patients suspected of having deep vein thrombosis to see if using these images can help train an AI to detect DVT more accurately.
-
Using apixaban to treat blood clots in cancer patients with low platelet counts
This study is testing if a new dose of the blood thinner apixaban can safely help cancer patients with low platelet counts manage blood clots without causing more bleeding.
-
Using machine learning to quickly detect deep vein thrombosis
This study is testing if a new machine learning tool can help doctors quickly rule out deep vein thrombosis in patients without needing an ultrasound every time.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.