Using compression gloves to reduce nerve pain from taxane chemotherapy
Official title: Tight Surgical Gloves to Prevent Chemotherapy-induced Peripheral Neuropathy: A Randomized Controlled Trial to Evaluate the Efficacy of Compression Therapy in Patients With Taxane-based Chemotherapy for Breast and Urogenital Cancer
Run by St.Gallen University of Applied Sciences · NCT06464536 · Data updated 2026-11-12
This study is testing whether wearing compression gloves can help reduce nerve pain for breast cancer and urogenital carcinoma patients receiving taxane chemotherapy.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 114 (estimated) |
| Sponsor | St.Gallen University of Applied Sciences Academic / other |
| Drugs / interventions | Chemotherapy |
| Locations | 1 site (Zurich) |
| Status | Recruiting |
| Started | February 3, 2025 |
| Main results expected | September 2025 |
| Study ends | March 2026 |
| Registry record updated | May 16, 2025 |
| Trial ID | NCT06464536 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults with breast cancer or urogenital carcinoma who are starting their first treatment with taxanes.
✕Probably not a fit
Patients with a history of neuropathy or those receiving other neurotoxic treatments may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effectiveness of wearing tight surgical gloves to alleviate chemotherapy-induced peripheral neuropathy (CIPN) in patients undergoing taxane-based treatments. It is a randomized controlled trial conducted at the Comprehensive Cancer Center Zurich, where participants will be assigned to either a compression glove group or a control group wearing non-compressing gloves. The primary goal is to determine if compression therapy can significantly reduce the incidence of moderate to severe CIPN during treatment cycles. The study will involve patients with breast cancer or urogenital carcinoma receiving specific taxane therapies.
Why it matters
Potential benefit: If successful, this approach could significantly improve the quality of life for patients undergoing taxane chemotherapy by reducing painful side effects.
How similar studies have gone: Previous studies have suggested that compression therapy may effectively reduce CIPN, indicating potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Mamma or Urogenital carcinoma * first treatment with Taxanes (nab-Paclitaxel, Paclitaxel, Docetaxel) * signed informed consent * sufficient proficiency in German or English Exclusion Criteria: * other therapy that could have caused peripheral neuropathy within the last 24 months (Taxane, Platin, Vincaalkaloids, etc.) * History of neuropathy such as Raynaud's phenomenon, fibromyalgia and diabetic polyneuropathy * Use of polyneuropathy medications including duloxetine; gabapentin/pregabalin; topical amitriptyline, ketamine, baclofen; oral cannabinoids; tricyclic antidepressants; and ganglioside monosialic acid * such impaired cognition that prevents participation in the study according to the assessment of the caregivers
Where it's running
-
University Hospital Zuerich
Zurich, Switzerland Recruiting
Study contacts
- Principal investigator: Anna Götz, PhD — Usz
- Study coordinator: Anna Götz, PhD
- Email: anna.goetz@usz.ch
- Phone: +41 43 253
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Cryocompression to prevent taxane-induced nerve damage in the arms and legs.
This study tests whether cooling and pressure applied to the arms and legs during taxane chemotherapy can prevent or reduce numbness, pain, or weakness from peripheral neuropathy in adults with breast or gynecologic cancer.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.