Using cola to relieve esophageal blockage in cancer patients

A Prospective, Randomized Controlled Study on Cola Ingestion for Bolus Impaction in Patients With Esophageal Cancer

This study is testing if drinking cola can help cancer patients with sudden food blockages in their esophagus feel better.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 50 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Fudan University (Academic / other)
• Locations: 1 site (Shanghai)
• Trial ID: NCT06652620 on ClinicalTrials.gov

What this trial studies

This study aims to evaluate the effectiveness of cola ingestion in improving the 24-hour remission rate of acute esophageal impaction in patients diagnosed with esophageal cancer. Participants must have primary esophageal lesions and experience a sudden complete obstruction of eating within the past week. The study will involve administering cola to these patients and observing the outcomes related to their esophageal impaction. The goal is to determine if cola can serve as a beneficial intervention for this condition.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 and older with primary esophageal lesions and acute esophageal impaction who have not consumed carbonated beverages prior to enrollment.

Not a fit: Patients with complete obstruction due to tumor progression or those with esophageal fistulas or stents will not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could provide a non-invasive method to relieve esophageal blockage in patients with esophageal cancer.

How similar studies have performed: While the use of cola for esophageal impaction is a novel approach, there is limited existing research on this specific intervention.

Eligibility criteria

Inclusion Criteria:

1. Patients with primary esophageal lesions diagnosed by pathology, being able to consume at least a liquid diet normally before and diagnosed by a physician with acute esophageal impaction (acute esophageal impaction refers to the sudden occurrence of complete obstruction of eating within the past week)
2. Prior to enrollment, the patient did not consume carbonated beverages such as cola, or any other treatment for esophageal impaction.
3. Age ≥ 18 years old, ECOG score is 0-2 points.
4. The subjects voluntarily enrolled and obtained an informed consent form signed by the patient or their legal representative.

Exclusion Criteria:

1. It is known that complete esophageal obstruction is caused by tumor progression.
2. Patients who have been diagnosed with or highly suspected of having esophageal fistula through endoscopy or imaging prior to enrollment.
3. Patients with nasogastric nutrition tube and esophageal stent implantation
4. Patients who have symptoms such as coughing and are unable to drink cola, or who are at serious risk of aspiration (Glasgow Coma Scale\<14 or previous history of aspiration).
5. Benign diseases such as gastroesophageal reflux, cardiac arrest, and congenital esophageal stenosis that can easily lead to foreign body impaction in the esophagus.
6. Patients with coagulation dysfunction, thrombocytopenia, or taking anticoagulant drugs that are medically considered contraindications for endoscopic examination and treatment.
7. According to the researchers' assessment, patients may not be able to cooperate with the examination and treatment, or there may be other factors that could force them to terminate the study midway, such as having other serious illnesses (including mental illnesses) that require concomitant treatment, severe abnormal laboratory test values, family or social factors, which may affect the safety of the patients or the collection of experimental data.

Where this trial is running

Shanghai

• Fudan University Shanghai Cancer Center — Shanghai, China (Recruiting)

Conditions Esophageal Cancer