Using clopidogrel to prevent heart issues in patients with early signs of coronary artery disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial evaluates the effectiveness and safety of clopidogrel as a preventive treatment for patients with subclinical coronary atherosclerosis who do not require revascularization. The study aims to determine if clopidogrel can reduce the risk of major adverse cardiovascular and cerebrovascular events in these patients. Participants will be randomly assigned to receive either clopidogrel or no antiplatelet therapy, allowing for a comparison of outcomes. The trial addresses a gap in current knowledge regarding primary prevention strategies for coronary artery disease.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male or female aged ≥40 years
* Patients with subclinical coronary atherosclerosis identified from coronary CT angiography or coronary angiography within 2 years without clinical events after an imaging study
* Without significant coronary artery stenosis (Diameter stenosis \>50%), which needs revascularization
* Agreement to give written informed consent

Exclusion Criteria:

* A history of a diagnosed cardiovascular or cerebrovascular disease (Type1 myocardial infarction, heart failure, peripheral artery disease, stroke, transient ischemic attack, carotid artery stenosis\>50%, carotid artery intervention)
* A history of coronary artery intervention or coronary artery bypass graft surgery, which needs chronic maintenance of antiplatelet therapy
* Absolute contraindication or allergy to clopidogrel
* Patients receiving anticoagulants for other comorbidities
* A history of Bleeding diathesis, known coagulopathy, or major bleeding, BARC class ≥3, resulting in the stop of antiplatelet agents
* Planned surgery or intervention which needs to stop antiplatelet agents ≥1 month
* Presence of non-cardiac comorbidity with life expectancy ≤ 5 years at randomization
* Females with pregnancy or breast-feeding
* Patients who are thought to be inappropriate for the trial based on physicians' decision

Where it's running

• Seoul National University Hospital
  Seoul, Other, South Korea Recruiting
• Andong Hospital
  Andong, South Korea Recruiting
• Dong-A University Hospital
  Busan, South Korea Recruiting
• Inje University Busan Paik Hospital
  Busan, South Korea Recruiting
• Kosin University Gospel Hospital
  Busan, South Korea Recruiting
• Pusan National University Hospital
  Busan, South Korea Recruiting

+11 more sites. See ClinicalTrials.gov for the full list.

Study contacts

• Study coordinator: Jung-Kyu Han, MD, PhD
• Email: hpcrates@gmail.com
• Phone: 821026765736

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.