Using chocolate scents to help children with anesthesia

Chocolate or Sevoflurane: Use of Parosmia to Facilitate More Cooperative Inhalation Inductions in Children

Not applicable Interventional Johns Hopkins University · NCT06449157

This study is testing if using chocolate scents can help make kids aged 5-12 feel less anxious and more cooperative when they are getting anesthesia for surgery.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment50 (estimated)
Ages5 Years to 13 Years
SexAll
SponsorJohns Hopkins University Academic / other
Locations1 site (Baltimore, Maryland)
Trial IDNCT06449157 on ClinicalTrials.gov

What this trial studies

This study explores the use of parosmia, a distortion of smell perception, to improve the inhalation induction experience for children undergoing anesthesia. By introducing a more pleasant scent, such as chocolate, during the administration of sevoflurane, the study aims to reduce anxiety and enhance cooperation in pediatric patients. The approach leverages the emotional connection between olfactory senses and memory, potentially leading to a more positive preoperative experience. The study focuses on children aged 5-12 years who are classified as ASA I or II and are coming from home for elective surgery.

Who should consider this trial

Good fit: Ideal candidates for this study are children aged 5-12 years who are in good health (ASA I or II) and are scheduled for elective surgery.

Not a fit: Patients who are undergoing emergent surgery or have severe health conditions (ASA III, IV, V) may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could significantly reduce anxiety and improve the overall experience of children undergoing anesthesia.

How similar studies have performed: While the use of olfactory stimuli in anesthesia is a novel approach, similar studies have shown promise in improving patient cooperation and reducing anxiety.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Ages of 5-12 years old
* American Society of Anesthesiologist physical status classification system (ASA) I and II
* Patients coming from home

Exclusion Criteria:

* Patients undergoing emergent surgery
* Patients who have not adequately maintained preoperative nothing per mouth/os (NPO) status
* Patients with inability to communicate verbally
* Tracheostomy patients
* ASA III , IV, V patients

Where this trial is running

Baltimore, Maryland

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions AnesthesiaPediatrics
Last reviewed 2026-06-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.