Using chlorination to reduce infections in newborns
Official title: Multi-component Chlorination Intervention to Reduce Neonatal Infections in Rural Health Facilities
Run by University of California, Berkeley · NCT06824350 · Data updated 2026-11-12
This study is testing if using chlorinated water in hospitals can help reduce infections in mothers and newborns in western Kenya.
Quick facts
| Study type | Interventional |
|---|---|
| Sex | All |
| Enrollment | 45450 (estimated) |
| Sponsor | University of California, Berkeley Academic / other |
| Locations | 2 sites (Berkeley, California and 1 other locations) |
| Status | Recruiting |
| Started | January 21, 2025 |
| Main results expected | July 2027 |
| Study ends | July 2027 |
| Registry record updated | October 13, 2026 |
| Trial ID | NCT06824350 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are pregnant adults or mature minors arriving at participating healthcare facilities to give birth.
✕Probably not a fit
Patients who may not benefit from this study include those who experience miscarriage or stillbirth, as well as those who cannot provide informed consent.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The CLEAN trial evaluates the effectiveness of a chlorination intervention in healthcare facilities in western Kenya to improve maternal and neonatal health outcomes. This cluster randomized controlled trial involves 36 public health facilities, where some will receive a passive chlorination system for water treatment and a reliable supply of sodium hypochlorite disinfectant. Both intervention and control facilities will also receive messaging on infection prevention and control. The study aims to assess the impact of this intervention on bacterial contamination in water supplies, healthcare worker hands, and high-touch surfaces, as well as the gut colonization of pathogenic and antibiotic-resistant bacteria in mothers and their newborns.
Why it matters
Potential benefit: If successful, this intervention could significantly reduce the incidence of infections and improve survival rates among neonates in low-resource settings.
How similar studies have gone: Other studies have shown promising results with chlorination and infection control measures in healthcare settings, indicating potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Facility Inclusion Criteria: * Public health care facility * 25 live births or more per month * Infrastructure compatible with inline chlorination device Participant Inclusion Criteria: * Pregnant adults/mature minors arriving at enrolled facilities to give birth and their neonates Facility Exclusion Criteria: * Existing facility-level chlorination Participant Exclusion Criteria: * Miscarriage (\<28 weeks gestation) * Stillbirth (for neonatal analysis only) * Unable to give informed consent/do not consent * Reside \>2 hours away from facility for enrollment into swab sampling cohort
Where it's running
-
Kenya Medical Research Institute
Nairobi, Kenya Recruiting -
University of California, Berkeley
Berkeley, California, United States Active not recruiting
Study contacts
- Principal investigator: Amy J Pickering, PhD — University of California, Berkeley
- Study coordinator: Amy J Pickering, PhD
- Email: amyjanel@gmail.com
- Phone: 1-510-410-2666
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.