Using CCTA to Manage Non-Obstructive Coronary Artery Disease

Serial Coronary CTA-based Plaque Progression Detection for Management of Coronary Heart Disease: a Randomised Controlled Trial

This study is testing if using a special heart scan called CCTA to manage non-obstructive coronary artery disease can help people control their cholesterol better and lower their risk of serious heart problems compared to regular care.

Quick facts

• Phase: NA
• Study type: Interventional
• Enrollment: 3100 (estimated)
• Ages: 18 Years to 80 Years
• Sex: All
• Sponsor: Jinling Hospital, China (other)
• Locations: 1 site (Nanjing, Jiangsu)
• Trial ID: NCT06843005 on ClinicalTrials.gov

What this trial studies

This study evaluates whether a management strategy based on coronary computed tomography angiography (CCTA) can improve lipid control and reduce major adverse cardiovascular events in patients with non-obstructive coronary artery disease. Participants will be randomly assigned to either a follow-up CCTA management group or a routine clinical management group. The study aims to compare the effectiveness of these two approaches over a three-year period, focusing on the incidence of cardiovascular events and all-cause mortality. The primary goal is to determine if CCTA follow-up leads to better outcomes than traditional management strategies.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 to 80 with a history of non-obstructive coronary artery disease lasting at least two years.

Not a fit: Patients who have experienced acute coronary syndrome or other significant cardiovascular events may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could significantly reduce the risk of major cardiovascular events in patients with non-obstructive coronary artery disease.

How similar studies have performed: Other studies have shown promise in using imaging techniques for managing coronary artery disease, suggesting this approach may be effective.

Eligibility criteria

Inclusion Criteria:

1. Age between 18 and 80 years old;
2. Known patients with non-obstructive coronary artery disease (disease duration ≥2 years);
3. Patients who agree to undergo follow-up CCTA examinations and cooperate in completing follow-up observations.

Exclusion Criteria:

1. Patients who have experienced ACS or PCI/CABG;
2. Patients who have experienced adverse cardiovascular and cerebrovascular events;
3. Patients who have undergone follow-up CCTA or DSA examinations before enrollment;
4. Patients with severe hepatic and renal dysfunction;
5. Patients with contraindications to CCTA examinations;
6. Patients with poor initial CCTA image quality or data loss.

Where this trial is running

Nanjing, Jiangsu

• Research Institute Of Medical Imaging Jinling Hospital — Nanjing, Jiangsu, China (RECRUITING)

Study contacts

• Study coordinator: Longjiang Zhang, MD

Conditions: Major Adverse Cardiovascular Events, Prevention, Coronary Artery Disease, CT Angiography