Using cardiac shock wave therapy to treat heart attacks without blocked arteries
The Effect of Cardiac Shock Wave Therapy in the Treatment of Myocardial Infarction With Non-obstructive Coronary Arteries: a Prospective, Randomized Controlled Clinical Study
NA · Shanghai 10th People's Hospital · NCT05935436
This study is testing if cardiac shock wave therapy can help people who have had a heart attack without blocked arteries feel better and improve their heart health.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 56 (estimated) |
| Ages | 18 Years to 85 Years |
| Sex | All |
| Sponsor | Shanghai 10th People's Hospital (other) |
| Locations | 1 site (Shanghai, Shanghai) |
| Trial ID | NCT05935436 on ClinicalTrials.gov |
What this trial studies
This trial investigates the safety and effectiveness of cardiac shock wave therapy (CSWT) for patients experiencing myocardial infarction with non-obstructive coronary arteries (MINOCA). It aims to provide a new treatment strategy for MINOCA, a condition that currently lacks effective treatment options. Participants aged 18 to 85 with specific inclusion criteria will be randomly assigned to receive either CSWT combined with conventional medical therapy or conventional therapy alone. The study will assess the impact of CSWT on cardiovascular outcomes in this patient population.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 to 85 who have been diagnosed with acute myocardial infarction and show no significant coronary artery blockage.
Not a fit: Patients with a history of coronary heart disease or those experiencing acute heart failure or severe valvular heart disease are unlikely to benefit from this study.
Why it matters
Potential benefit: If successful, this treatment could offer a new therapeutic option for patients suffering from MINOCA, potentially improving their cardiovascular health and outcomes.
How similar studies have performed: While there is limited research on cardiac shock wave therapy specifically for MINOCA, similar approaches in treating other cardiac conditions have shown promise, indicating potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged between 18 and 85 years old * The initial diagnosis is acute myocardial infarction * Coronary angiography shows coronary stenosis \<50% * Abnormal D-SPECT myocardial perfusion images * Voluntary informed consent signed Exclusion Criteria: * Previous history of coronary heart disease, received percutaneous coronary intervention, coronary artery bypass surgery or myocardial infarction (MI) * Hemodynamic instability * Acute heart failure * Severe valvular heart disease requiring surgical treatment * Severe liver and kidney diseases * Malignant tumors with expected survival of less than one year * Patients with severe bleeding tendency * Pregnant women * Intervening coronary ischemic events
Where this trial is running
Shanghai, Shanghai
- Department of Cardiology, Shanghai Tenth People's Hospital — Shanghai, Shanghai, China (RECRUITING)
Study contacts
- Study coordinator: Weijing Liu, MD, PhD
- Email: liuweijing98@sina.com
- Phone: +86 18917684041
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Myocardial Infarction With Non-obstructive Coronary Arteries, Cardiac Shock Wave Therapy, myocardial infarction with non-obstructive coronary arteries, cardiac shock wave therapy, D-SPECT, myocardial infarction