Using cardiac MRI to study healthy women for heart disease insights

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research aims to apply cardiac magnetic resonance imaging (CMR) to women without heart disease to establish a normal reference control group. The study will enroll 40 healthy women who will undergo various assessments, including exercise treadmill tests and CMR scans, to gather data on cardiovascular health. By comparing these results to those of women with small artery heart disease, the study seeks to enhance understanding of CMR's utility in diagnosing and treating this condition. The findings may lead to improved noninvasive diagnostic techniques for women suffering from small vessel heart disease.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Women without signs and symptoms of myocardial ischemia (chest pain, abnormal stress testing, abnormal noninvasive testing).
2. No cardiac risk factors by Framingham/NCEP criteria, age and BMI matched to the Cardiac Syndrome X population, and a normal exercise stress test.

Exclusion Criteria:

1. Contraindications to CMR testing (metal devices in chest, claustrophobia, known angioedema).
2. Contraindication to Adenosine or Lexiscan (regadenoson) including heart block (second and third degree) and sinus node disease, significant COPD/asthma, or systemic hypotension (\<90 mmHg).
3. Contraindication to Dobutamine including severe systemic hypertension (≥ 220/120 mmHg), unstable angina, significant aortic valve stenosis, complex cardiac arrhythmia including uncontrolled atrial fibrillation, hypertrophic obstructive cardiomyopathy, myocarditis, endocarditis, pericarditis, or uncontrolled congestive heart failure.
4. Contraindication to Gadolinium (renal impairment).
5. Any renal disease.
6. Pregnant and lactating women.
7. Inability to perform exercise, eg. orthopedic limitations.
8. Allergy to animal dander.

Where it's running

• Cedars-Sinai Women's Heart Center
  Los Angeles, California, United States Recruiting

Study contacts

• Principal investigator: C. Noel Bairey Merz, MD — Cedars-Sinai Medical Center
• Study coordinator: Nicole Tovar
• Email: nicole.tovar@cshs.org
• Phone: 310-248-6960

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.