Using cardiac index monitoring to help patients with heart injury wean off ventilation

A Randomized Controlled Study on Continuous Monitoring of Cardiac Index Variability to Guide Patients With Perioperative Myocardial Injury to Wean From Mechanical Ventilation

This study tests if using new heart monitoring methods can help patients with heart injury breathe on their own more successfully after surgery compared to standard methods.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 200 (estimated)
• Ages: 18 Years to 80 Years
• Sex: All
• Sponsor: Peking University People's Hospital (Academic / other)
• Locations: 1 site (Beijing)
• Trial ID: NCT06240104 on ClinicalTrials.gov

What this trial studies

This clinical trial aims to evaluate the effectiveness of integrating continuous cardiac index variability indicators with existing weaning standards for patients experiencing myocardial injury during surgery. Participants will be monitored for their cardiac index prior to the weaning process, and those showing a significant increase will be considered for extubation. The study will compare the success rates of weaning between a group using the new indicators and a control group following traditional standards. The goal is to determine if the new approach leads to better patient outcomes and fewer complications.

Who should consider this trial

Good fit: Ideal candidates are adults over 18 years old who have experienced perioperative myocardial injury and require mechanical ventilation for more than 24 hours.

Not a fit: Patients who have had a cumulative mechanical ventilation time of 24 hours or less, or those unable to cooperate with treatment, may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could improve the weaning success rate for patients with myocardial injury, leading to better recovery outcomes.

How similar studies have performed: While this approach is innovative, similar studies have shown promise in improving weaning outcomes through enhanced monitoring techniques.

Eligibility criteria

Inclusion Criteria:

* Perioperative myocardial injury patients
* Age\>18 years;
* Acute Physiology and Chronic Health Evaluation II (APACHEII)\>8 ;
* The weaning process has not yet started after surgery;
* Expected postoperative cumulative mechanical ventilation time\>24 hours.

Exclusion Criteria:

* Pregnancy or childbirth less than 42 days;
* Patients and their families are unable to cooperate with treatment;
* The cumulative actual mechanical ventilation time after surgery is ≤ 24 hours;
* Interruption of mechanical ventilation treatment due to death or other reasons before entering the weaning process;
* Patients who retain artificial airways after weaning;
* Patients who plan to start non-invasive mechanical ventilation treatment immediately after weaning.

Where this trial is running

Beijing

• Peking University People's Hospital — Beijing, China (Recruiting)

Study contacts

• Study coordinator: Shu Li, doctor

Conditions Myocardial Ischaemia During Surgery; cardiac index variability; wean from mechanical ventilation; perioperative myocardial injury