Using CAN1012 to treat advanced solid tumors

A Phase 1, Dose Escalation, Open-Label Study of Intratumoral CAN1012 in Subjects With Unresectable or Metastatic Advanced Solid Tumors

This study is testing a new treatment called CAN1012 for people with advanced solid tumors who can't use standard therapies to see if it helps fight their cancer safely.

Quick facts

• Phase: Phase 1
• Study type: Interventional
• Enrollment: 36 (estimated)
• Ages: 18 Years to 80 Years
• Sex: All
• Sponsor: CanWell Pharma Inc. (Industry-sponsored)
• Drugs / interventions: chemotherapy, immunotherapy
• Locations: 2 sites (Woburn, Massachusetts and 1 other locations)
• Trial ID: NCT04987112 on ClinicalTrials.gov

What this trial studies

This Phase 1 clinical trial evaluates the safety and efficacy of CAN1012, a selective TLR7 agonist, administered through intratumoral injection in patients with advanced solid tumors who are not eligible for standard therapies. The study employs a dose escalation design, enrolling subjects in cohorts of three at each dose level to assess the treatment's effects. It aims to determine the optimal dose and monitor any potential side effects while providing preliminary data on its effectiveness against metastatic cancer.

Who should consider this trial

Good fit: Ideal candidates include adults over 18 with metastatic or locally advanced solid tumors that have progressed despite standard therapies.

Not a fit: Patients with early-stage tumors or those who are candidates for standard therapies may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could offer a new therapeutic option for patients with advanced solid tumors who have exhausted standard care options.

How similar studies have performed: While this approach is novel in its specific application, similar studies using TLR agonists have shown promise in other contexts.

Eligibility criteria

Inclusion Criteria:

1. Able and willing to provide written informed consent and willing to comply with the study's requirements.
2. Male or female age \>18 years at screening.
3. Metastatic or locally advanced solid tumor that has progressed on, is refractory to, or for which there is no efficacious standard of care therapy.
4. Demonstrate adequate organ function as defined below. All screening laboratory assessments should be performed within 14 days of treatment initiation.
5. Performance status of 0 or 1 on the ECOG Performance Scale.
6. Life expectancy \>12 weeks at Baseline.
7. Women of childbearing potential must have negative serum pregnancy test within 3 days prior to receiving the first study drug administration.
8. For women of childbearing potential, must be willing to use an adequate method of contraception from 30 days prior to the first study drug administration and 120 days following last day of study drug administration.
9. Male subjects of childbearing potential must be surgically sterile or must agree to use adequate method of contraception during the study and at least 120 days following the last day of study drug administration.

Exclusion Criteria:

1. Received prior TLR7/8 agonists (excluding topical agents).
2. Has untreated or uncontrolled central nervous system (CNS) involvement.
3. Will receive concurrent chemotherapy, immunotherapy, biologic, hormonal therapy, or other therapies for cancer.
4. Received systemic interferon alfa (IFNα) prior to enrollment.
5. Unresolved toxicities from prior therapy, defined as having not resolved to CTCAE v5.0 Grade 0 or 1, with exception of endocrinopathies from prior therapy, alopecia, and vitiligo.
6. Treatment with systemic corticosteroids.
7. Concomitant or planned use of sensitive substrates of major cytochrome P450 enzymes.
8. Has an active infection requiring systemic therapy.
9. Has known active infection with the human immunodeficiency virus,
10. Unstable/inadequate cardiac function.
11. Uncontrolled concurrent illness.
12. A history of interstitial lung disease.
13. A history of coagulopathy resulting in uncontrolled bleeding or other bleeding disorders.
14. Participated in a clinical study of an investigational agent within 30 days of screening.
15. Has known psychiatric, substance abuse, or other disorders that would interfere with cooperation with the requirements of the study in the opinion of the investigator.
16. Is pregnant or breastfeeding.

Where this trial is running

Woburn, Massachusetts and 1 other locations

• CanWellPharma — Woburn, Massachusetts, United States (Recruiting)
• Providence Cancer Institute — Portland, Oregon, United States (Recruiting)

Study contacts

• Study coordinator: Rongchu Chen

Conditions Solid Tumor; Cancer Metastatic