Using bumetanide to treat Alzheimer's disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of bumetanide, a diuretic, on patients with biologically confirmed Alzheimer's disease. The research aims to evaluate the safety and tolerability of bumetanide, as well as its clinical and biomarker effects in individuals with mild cognitive impairment or mild dementia. The study builds on previous findings that suggest bumetanide may influence Alzheimer's disease pathology by altering gene expression related to the APOE genotype. Participants will receive either bumetanide or a placebo while their health and cognitive function are monitored.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Mild cognitive impairment or mild dementia due to Alzheimer's disease.
* Alzheimer's disease medications are planned to remain stable throughout.
* Willingness and ability to complete all aspects of the study including assessments, neuropsychological testing, and MRI.

Exclusion Criteria:

* Clinically significant abnormalities in screening laboratory tests
* Chronic liver disease
* Renal insufficiency
* Poorly managed hypertension
* Participants taking the following concomitant medications, based on the current Prescribing Information for bumetanide: lithium, drugs with ototoxic potential, drugs with nephrotoxic potential, probenecid, and indomethacin.

Where it's running

• Stanford University
  Stanford, California, United States Recruiting

Study contacts

• Principal investigator: Kyan Younes, MD — Stanford University
• Study coordinator: Mina L Kim
• Email: minakim@stanford.edu
• Phone: (650) 387-1559

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.