Clinical trial Recruiting at 1 site Phase 1 Interventional Ages 30 to 50

Using bromelain and chlorhexidine gels to treat periodontal pockets after cleaning

Official title: Evaluation of 2%Bromelain Gel With 0.2%Chlorhexidine Gel as Subgingival Local Drug Delivery Following Scaling and Root Planing in Stage II/III and Grade B Periodontitis -Randomized Control Clinical Trail

Run by Krishnadevaraya College of Dental Sciences & Hospital · NCT06505759 · Data updated 2026-11-12

This study is testing if using bromelain or chlorhexidine gels after a deep cleaning can help people with gum disease heal better than just cleaning alone.

More Periodontal Pocket trials

Quick facts

PhasePhase 1
Study typeInterventional
Ages30 Years to 50 Years
SexAll
Enrollment36 (estimated)
SponsorKrishnadevaraya College of Dental Sciences & Hospital
Academic / other
Locations1 site (Bengaluru, Karnataka)
StatusRecruiting
StartedJuly 1, 2024
Main results expectedJuly 2025
Study endsJuly 2025
Registry record updatedJanuary 13, 2025
Trial IDNCT06505759 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are individuals aged 30-50 with chronic periodontitis and probing depths of 4-6mm.

Probably not a fit

Patients who have undergone any periodontal therapy in the past 6 months or are pregnant may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of 2% bromelain gel and 0.2% chlorhexidine gel as local drug delivery methods following scaling and root planing (SRP) in patients with Stage II/III and Grade B periodontitis. A total of 36 periodontal sites with probing depths of 4-6mm are divided into three groups: one receiving SRP alone, another receiving SRP followed by bromelain gel, and the last receiving SRP followed by chlorhexidine gel. Patients are monitored at 1 week, 4 weeks, and 12 weeks post-treatment to assess outcomes.

Why it matters

Potential benefit: If successful, this approach could enhance the effectiveness of periodontal treatment and improve patient outcomes.

How similar studies have gone: Previous studies have shown promise in using local drug delivery methods for periodontal treatment, suggesting potential success for this approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patient with have chronic periodontitis in the age group between 30-50 years.
* Patients having ≥20 teeth.

  -.Patients with radiographic evidence of bone loss in atleast two teeth.
* Patients who are systematically healthy.
* Patients with localized pockets with probing depth of ≤ 5mm.
* Patients who are cooperative and able to attend the hospital for regular follow-up.

Exclusion Criteria:

* Patients who have received any surgical or nonsurgical therapy during past 6months
* Pregnant or lactating females.
* Use of systemic antibiotics in the past 6 months.
* Patient who are not willing to give a written informed consent

Where it's running

  • Dr. NALLAGATLA VAMSI VENKATA KRISHNA SAI
    Bengaluru, Karnataka, India
    Recruiting

Study contacts

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.