Using bromelain and chlorhexidine gels to treat periodontal pockets after cleaning
Evaluation of 2%Bromelain Gel With 0.2%Chlorhexidine Gel as Subgingival Local Drug Delivery Following Scaling and Root Planing in Stage II/III and Grade B Periodontitis -Randomized Control Clinical Trail
This study is testing if using bromelain or chlorhexidine gels after a deep cleaning can help people with gum disease heal better than just cleaning alone.
Quick facts
| Phase | Phase 1 |
|---|---|
| Study type | Interventional |
| Enrollment | 36 (estimated) |
| Ages | 30 Years to 50 Years |
| Sex | All |
| Sponsor | Krishnadevaraya College of Dental Sciences & Hospital Academic / other |
| Locations | 1 site (Bengaluru, Karnataka) |
| Trial ID | NCT06505759 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of 2% bromelain gel and 0.2% chlorhexidine gel as local drug delivery methods following scaling and root planing (SRP) in patients with Stage II/III and Grade B periodontitis. A total of 36 periodontal sites with probing depths of 4-6mm are divided into three groups: one receiving SRP alone, another receiving SRP followed by bromelain gel, and the last receiving SRP followed by chlorhexidine gel. Patients are monitored at 1 week, 4 weeks, and 12 weeks post-treatment to assess outcomes.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 30-50 with chronic periodontitis and probing depths of 4-6mm.
Not a fit: Patients who have undergone any periodontal therapy in the past 6 months or are pregnant may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could enhance the effectiveness of periodontal treatment and improve patient outcomes.
How similar studies have performed: Previous studies have shown promise in using local drug delivery methods for periodontal treatment, suggesting potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient with have chronic periodontitis in the age group between 30-50 years. * Patients having ≥20 teeth. -.Patients with radiographic evidence of bone loss in atleast two teeth. * Patients who are systematically healthy. * Patients with localized pockets with probing depth of ≤ 5mm. * Patients who are cooperative and able to attend the hospital for regular follow-up. Exclusion Criteria: * Patients who have received any surgical or nonsurgical therapy during past 6months * Pregnant or lactating females. * Use of systemic antibiotics in the past 6 months. * Patient who are not willing to give a written informed consent
Where this trial is running
Bengaluru, Karnataka
- Dr. NALLAGATLA VAMSI VENKATA KRISHNA SAI — Bengaluru, Karnataka, India (Recruiting)
Study contacts
- Study coordinator: DR .Prabhuji MLV, MDS
- Email: prabhujimlv@gmail.com
- Phone: 9448057407
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.