Using Brentuximab Vedotin to treat newly diagnosed Classical Hodgkin Lymphoma in young patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of Brentuximab vedotin as part of a new treatment regimen for children, adolescents, and young adults with newly diagnosed classical Hodgkin lymphoma. The approach aims to replace certain chemotherapy agents to enhance early response rates and reduce the need for radiation therapy. Patients will be assessed using PET/CT scans to determine their response to treatment, with adjustments made for those who do not achieve complete metabolic remission. The goal is to maintain high event-free survival rates while minimizing long-term side effects.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Ages \>=2\~\<35 years at the time of enrollment;
* Patients with newly diagnosed, pathologically confirmed classical Hodgkin lymphoma (HL) by at least 2 tertiary referral centers for pathology;
* Adequate organ function;
* Patients and/or their parents or legal guardians sign a written informed consent;

Exclusion Criteria:

* Patients with nodular lymphocyte-predominant HL;
* Patients with an immunodeficiency that existed prior to diagnosis; such as primary immunodeficiency syndromes, organ transplant recipients and children on current systemic immunosuppressive agents are not eligible;Patients known to be positive for HIV are not eligible.
* Patients who are pregnant; Lactating females who plan to breastfeed.
* Patients who received systemic corticosteroids within 28 days of enrollment on this protocol

Where it's running

• Shanghai Children's Medical Center
  Shanghai, China Recruiting

Study contacts

• Principal investigator: Yi Jin Gao, Md — Shanghai Children's Medical Center
• Study coordinator: Yi Jin Gao, Md
• Email: gaoyijin@scmc.com.cn
• Phone: 86-21-38087513

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.