Using breath-hold methods with and without oxygen to improve liver MRI image quality

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This within-subject, randomized crossover study at UCSF uses a 3T MRI to compare two breath-hold conditions—functional residual capacity (end-expiration) with and without preoxygenation—in healthy adults. Each participant will undergo non-contrast abdominal MRI with T2-weighted and MRCP sequences during both breath-hold conditions in randomized order, serving as their own control. MRI-compatible pulse oximetry will monitor oxygen saturation and two blinded radiologists will grade motion artifacts and overall image quality using a standardized 5-point scale. The single visit lasts about 45–60 minutes and includes breath-hold training followed by one imaging session.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Subject must be within 18-75 years of age;
* Subject must be able to hear and understand instructions without assistive devices;
* Subject must provide written informed consent;
* Subject has the necessary mental capacity to understand instructions, and is able to comply with protocol requirements;
* Subject is able to remain still for duration of imaging procedure (approximately 30-45 minutes)

Exclusion Criteria:

* Subjects with a weight greater than 499 lbs;
* Subjects that have metallic/conductive or electrically/magnetically active implants without Magnetic Resonance (MR) Safe or Magnetic Resonance (MR) Conditional labeling, with the exception of dental devices/fillings, surgical clips, and surgical staples determined to be safe for MRI scanning by a physician investigator;
* Subjects that have implants with MR Unsafe labeling;
* Subjects that have implants labeled as MR Conditional by the manufacturer for which the allowable conditions are not expected to be achieved by the MR environment or scan protocol;
* Subjects who have a contraindication to MRI per the screening policy of the participating site;
* Subjects with any respiratory or cardiovascular condition that could compromise safe breath holding;
* Subjects who are female and pregnant

Where it's running

• University of California, San Francisco
  San Francisco, California, United States Recruiting

Study contacts

• Principal investigator: John P Roberts, MD — University of California, San Francisco
• Study coordinator: John P Roberts, MD
• Email: John.Roberts@ucsf.edu
• Phone: 415-353-3677

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.