Using brain stimulation to improve navigation skills

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study examines how transcranial magnetic stimulation (TMS) affects spatial processing during goal-directed navigation tasks. Participants will engage in virtual navigation while receiving either active or sham TMS to the parietal cortex, with their brain activity monitored using EEG and MRI. The goal is to determine if modulating brain oscillations can enhance spatial encoding of rewards and influence decision-making during navigation. The study involves a randomized control design with multiple sessions over two weeks.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Be between the ages of 18 and 55 years old.
2. Not received substance abuse treatment within the previous 30 days.
3. Be in stable mental and physical health.
4. If female, test non-pregnant.
5. No evidence of focal or diffuse brain lesion on MRI.
6. Be willing to provide informed consent.
7. Be able to comply with protocol requirements and likely to complete all study procedures.

Exclusion Criteria:

1. Contraindication to MRI (e.g., presence of metal in the skull, orbits or intracranial cavity, claustrophobia).
2. Contraindication to rTMS (history of neurological disorder or seizure, increased intracranial pressure, brain surgery, or head trauma with loss of consciousness for \> 15 minutes, implanted electronic device, metal in the head, or pregnancy).
3. History of autoimmune, endocrine, viral, or vascular disorder affecting the brain.
4. History or MRI evidence of neurological disorder that would lead to local or diffuse brain lesions or significant physical impairment.
5. Life time history of mental disorders such as: Bipolar Affective disorder (BPAD), Schizophrenia, Post-traumatic Stress disorder (PTSD) or Dementia or Major Depression.

uninterruptable central nervous system medication.

Where it's running

• Rutgers University - Newark
  Newark, New Jersey, United States Recruiting

Study contacts

• Principal investigator: Travis E Baker — Rutgers University
• Study coordinator: Travis E Baker, PhD
• Email: travis.e.baker@rutgers.edu
• Phone: 973-353-5485

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.