Using brain stimulation to improve language function in primary progressive aphasia
Effects of Transcranial Direct Current Stimulation (tDCS) on Inhibition and Brain Function in Primary Progressive Aphasia
NA · Centre Hospitalier Universitaire de Nice · NCT06473714
This study is testing whether a type of brain stimulation can help improve language skills in people with primary progressive aphasia.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Centre Hospitalier Universitaire de Nice (other) |
| Locations | 1 site (Nice) |
| Trial ID | NCT06473714 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of transcranial direct current stimulation (tDCS) on brain function and inhibition in individuals diagnosed with primary progressive aphasia (PPA). By applying a small electrical current to the scalp, the study aims to enhance neuronal activity in targeted brain regions associated with language processing. Participants will undergo treatment sessions to assess changes in their language abilities and executive functions compared to a control group. The research seeks to explore the potential for neuroplasticity in the brains of individuals with PPA.
Who should consider this trial
Good fit: Ideal candidates are right-handed adults over 18 years old with a diagnosis of primary progressive aphasia who can read and speak French.
Not a fit: Patients with severe cognitive or language disorders, neurodevelopmental or non-degenerative neurological disorders, or those with contraindications to tDCS may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved language function and quality of life for patients with primary progressive aphasia.
How similar studies have performed: While the use of tDCS in language disorders is an emerging field, there have been promising results in similar studies exploring its effects on cognitive functions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Be a male or female over the age of 18 with a primary progressive aphasia diagnosis * Available for treatment and testing sessions * able to read and speak French * Be right-handed Exclusion Criteria: * Presence of neurodevelopmental disorders or non-degenerative neurological disorders * Post-stroke aphasia * Language or cognitive disorders too severe to allow task performance or communication * Pre-existing psychiatric disorders; severe depression, schizophrenia * People with pacemakers or metal implants, epilepsy * Presence of a medical condition that represents a contraindication to tDCS * Active use of psychotropic drugs * Treatment with tDCS or TMS in the last 3 months * Additional language therapy * Pregnancy or breast-feeding
Where this trial is running
Nice
- CHU de Nice — Nice, France (RECRUITING)
Study contacts
- Principal investigator: Auriane Gros, Pr — Centre Hospitalier Universitaire de Nice
- Study coordinator: Auriane Gros, Pr
- Email: gros.a2@chu-nice.fr
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Aphasia, Primary Progressive