Using brain stimulation to improve language function in primary progressive aphasia
Official title: Effects of Transcranial Direct Current Stimulation (tDCS) on Inhibition and Brain Function in Primary Progressive Aphasia
Run by Centre Hospitalier Universitaire de Nice · NCT06473714 · Data updated 2026-11-12
This study is testing whether a type of brain stimulation can help improve language skills in people with primary progressive aphasia.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | Centre Hospitalier Universitaire de Nice Academic / other |
| Locations | 1 site (Nice) |
| Status | Recruiting |
| Started | November 4, 2024 |
| Main results expected | September 2027 |
| Study ends | September 2027 |
| Registry record updated | November 5, 2024 |
| Trial ID | NCT06473714 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are right-handed adults over 18 years old with a diagnosis of primary progressive aphasia who can read and speak French.
✕Probably not a fit
Patients with severe cognitive or language disorders, neurodevelopmental or non-degenerative neurological disorders, or those with contraindications to tDCS may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effects of transcranial direct current stimulation (tDCS) on brain function and inhibition in individuals diagnosed with primary progressive aphasia (PPA). By applying a small electrical current to the scalp, the study aims to enhance neuronal activity in targeted brain regions associated with language processing. Participants will undergo treatment sessions to assess changes in their language abilities and executive functions compared to a control group. The research seeks to explore the potential for neuroplasticity in the brains of individuals with PPA.
Why it matters
Potential benefit: If successful, this approach could lead to improved language function and quality of life for patients with primary progressive aphasia.
How similar studies have gone: While the use of tDCS in language disorders is an emerging field, there have been promising results in similar studies exploring its effects on cognitive functions.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Be a male or female over the age of 18 with a primary progressive aphasia diagnosis * Available for treatment and testing sessions * able to read and speak French * Be right-handed Exclusion Criteria: * Presence of neurodevelopmental disorders or non-degenerative neurological disorders * Post-stroke aphasia * Language or cognitive disorders too severe to allow task performance or communication * Pre-existing psychiatric disorders; severe depression, schizophrenia * People with pacemakers or metal implants, epilepsy * Presence of a medical condition that represents a contraindication to tDCS * Active use of psychotropic drugs * Treatment with tDCS or TMS in the last 3 months * Additional language therapy * Pregnancy or breast-feeding
Where it's running
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CHU de Nice
Nice, France Recruiting
Study contacts
- Principal investigator: Auriane Gros, Pr — Centre Hospitalier Universitaire de Nice
- Study coordinator: Auriane Gros, Pr
- Email: gros.a2@chu-nice.fr
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.