Using brain stimulation and dual tasks to improve symptoms in Parkinson's disease
"Transcranial Direct Current Stimulation and Dual Tasks in Parkinson's Disease-tDCS&DT in PD"
This study is testing if combining brain stimulation with special exercises can help improve walking and thinking skills in people with Parkinson's disease.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 40 Years to 85 Years |
| Sex | All |
| Sponsor | Casa di Cura Privata del Policlinico SpA Academic / other |
| Locations | 1 site (Milano, MI) |
| Trial ID | NCT05871359 on ClinicalTrials.gov |
What this trial studies
This project evaluates the effects of transcranial Direct Current Stimulation (tDCS) combined with dual task training on patients with Parkinson's disease. The study involves a randomized controlled design with 30 participants divided into two groups, one receiving real tDCS and the other a sham treatment. Each participant will undergo 12 rehabilitation sessions over six weeks, with assessments of motor and cognitive profiles at baseline, post-treatment, and 12 weeks later. The aim is to determine if tDCS enhances the benefits of dual task training on walking and cognitive performance.
Who should consider this trial
Good fit: Ideal candidates are patients with Parkinson's disease who can walk 100 meters and have a Mini Mental State Examination score above 21.
Not a fit: Patients with severe cognitive impairments or other disabling neurological conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly improve motor and cognitive functions in patients with Parkinson's disease.
How similar studies have performed: Previous studies have shown promise in using tDCS for rehabilitation in Parkinson's disease, indicating potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Parkinson's disease patient (Hoehn and Yahr I-III); * Ability to walk with or without aid for 100 meters, * Mini Mental State Examination\> 21, * Ability to express informed consent Exclusion Criteria: * Inability of the patient to understand or perform the task based on the evaluation and judgment of the referring neuropsychologist and the investigator, and / or to sign or initial the informed consent; * History of other previous, disabling neurological diseases (e.g., Stroke cerebri, Alzheimer's Disease, Multiple Sclerosis and Disabling Peripheral Neuropathy) and / or ongoing psychiatric diseases (e.g., major depression); * Presence of contraindications to stimulation according to the most recent guidelines; * Brain metal implants- Pace-makers, brain stimulators, cochlear implants- Pregnancy status (for women); * Patient denial of informed consent.
Where this trial is running
Milano, MI
- Dipartimento di scienze neuroriabilitative, Casa di Cura del Policlinico — Milano, Mi, Italy (Recruiting)
Study contacts
- Study coordinator: Paola Antoniotti
- Email: antoniottipaola@gmail.com
- Phone: 00393474955464
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.