Using brain neurotechnology to enhance mirror therapy for stroke recovery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project aims to evaluate the effects of transcranial random noise stimulation (tRNS) combined with mirror therapy (MT) on stroke patients. The study will compare the effectiveness of unilateral and bilateral MT approaches augmented with tRNS against control interventions. By measuring health outcomes such as motor function, daily living activities, quality of life, and brain activity through EEG, the research seeks to identify the optimal combination of therapies for enhancing recovery. This innovative approach aims to leverage brain neurotechnology to improve rehabilitation outcomes for stroke survivors.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. ≥ 3 months onset from a first-ever unilateral stroke;
2. an initial FMA scores between 18 to 56, indicating moderate to mild upper extremity motor impairment (Thielman, Kaminski, \& Gentile, 2008);
3. age between 35 to 85;
4. no excessive spasticity in any of the joints of the affected arm (shoulder, elbow, wrist and fingers);
5. ability to follow instructions and perform tasks (Mini Mental State Examination scores ≥24);
6. no participation in any neurorehabilitation experiments or drug clinical trials and
7. willing to provide written informed consent.

Exclusion Criteria:

1. contradiction to tRNS including a history of epilepsy, pregnant, having pacemakers and metallic implants in the neck and heads (Rossi, Hallett, Rossini, Pascual-Leone, \& Safety of, 2009);
2. History of drug or alcohol abuse(Rossi et al., 2009);
3. concomitant neurological conditions such as dementia, Parkinson's disease, brain tumor, brain injury and other brain diseases (such as intracranial hypertension or cerebral edema);
4. Botulinum toxin injections 3 months before enrollment
5. have unstable cardiovascular status such as uncontrolled hypertension or New York Heart Association (NYHA) Class III/IV heart failure or are not suitable for receiving tRNS by the physician's assessments.

Where it's running

• Chang Gung Memotial Hospital
  Taoyuan, Taiwan Recruiting

Study contacts

• Study coordinator: Ching-yi Wu, ScD
• Email: cywu@mail.cgu.edu.tw
• Phone: #886-3-2118800

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.