Using brain imaging to predict outcomes after epilepsy surgery in children
Official title: RESting-state Functional MRI for Prediction of Post-surgical Prognosis In Pediatric Drug-Resistant Epilepsy
Run by Fondation Ophtalmologique Adolphe de Rothschild · NCT04451278 · Data updated 2026-11-12
This study is testing if brain scans can help doctors predict how well children with hard-to-treat epilepsy will do after surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 6 Years to 18 Years |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | Fondation Ophtalmologique Adolphe de Rothschild Research network |
| Locations | 1 site (Paris, PARIS) |
| Status | Recruiting |
| Started | October 30, 2020 |
| Main results expected | October 2027 |
| Study ends | April 2028 |
| Registry record updated | January 5, 2026 |
| Trial ID | NCT04451278 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are children aged 6 to 18 years who are scheduled to receive an MRI for lesional drug-resistant epilepsy.
✕Probably not a fit
Patients who have contraindications to MRI or a history of intracranial surgery may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study utilizes resting-state functional MRI (r-fMRI) to analyze brain networks in children aged 6 to 18 who are undergoing surgery for drug-resistant epilepsy. By applying graph theory to the r-fMRI data, the study aims to identify quantifiable parameters that can help predict individual prognosis post-surgery. The approach allows for the assessment of brain network effectiveness without requiring active participation from the patients. This innovative methodology seeks to provide insights that could enhance surgical decision-making for pediatric epilepsy patients.
Why it matters
Potential benefit: If successful, this study could lead to improved prognostic assessments for children undergoing epilepsy surgery, potentially enhancing surgical outcomes.
How similar studies have gone: While the application of graph theory to r-fMRI in this context is novel, similar studies in other areas have shown promising results in predicting outcomes based on brain network analysis.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient aged between 6 and 18 years * Receiving an MRI for lesional drug-resistant epilepsy * Affiliated or beneficiary of a social security plan * Whose parents or guardians have received information about the study and have given their express consent to participate in the study Exclusion Criteria: * Contraindication to absolute or relative MRI (in particular, pregnant or breastfeeding women) * History of intracranial surgery * MRI performed under general anesthesia
Where it's running
-
Fondation A De Rothschild
Paris, Paris, France Recruiting
Study contacts
- Principal investigator: Sidney KRYSTAL — Adolphe de Rothschild Fondation Hospital
- Study coordinator: Sidney KRYSTAL
- Email: skrystal@for.paris
- Phone: 01 48 03 65 65
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.