Using botulinum toxin to help close open abdomen cases
Botulinum Toxin Injection in the Treatment of Open Abdomen
This study is testing if botulinum toxin injections can help patients with an open abdomen heal faster and improve the closure of their abdominal wall.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 30 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Oulu Academic / other |
| Locations | 1 site (Oulu) |
| Trial ID | NCT04283916 on ClinicalTrials.gov |
What this trial studies
This study involves administering botulinum toxin injections to 30 patients with an open abdomen, aiming to evaluate its effectiveness in facilitating faster and better closure of the abdominal wall. The injections will be given within 72 hours of the open abdomen condition, targeting specific areas on both sides of the abdomen. The underlying hypothesis is that the toxin will relax the abdominal wall muscles, potentially improving surgical outcomes.
Who should consider this trial
Good fit: Ideal candidates for this study are patients who have an open abdomen due to any medical indication.
Not a fit: Patients with a history of previous incisional hernia in the midline or those not undergoing active treatment may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved closure rates and outcomes for patients with open abdomen conditions.
How similar studies have performed: While botulinum toxin has been used in other abdominal applications, its use specifically for open abdomen treatment has limited prior study, making this approach relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Open abdomen Exclusion Criteria: * Previous incisional hernia in midline * Patient is not in active treatment
Where this trial is running
Oulu
- Oulu University Hospital — Oulu, Finland (Recruiting)
Study contacts
- Study coordinator: Elisa Mäkäräinen-Uhlbäck, M.D.
- Email: elisa.makarainen-uhlback@ppshp.fi
- Phone: +358505794011
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.