Using Botox to treat jaw stiffness in head and neck cancer patients after radiation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project investigates the effectiveness of Botulinum toxin (Botox) injections into the masticatory muscles of head and neck cancer patients who experience trismus following radiation therapy. The intervention involves echo-guided injections of Botox, combined with oral rehabilitation exercises, aimed at alleviating muscle tension and spasms. The study will evaluate improvements in mouth opening range, quality of life, trismus severity, and pain levels to assess the treatment's efficacy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Aged over 18 years old;
2. Head and neck cancer patients must have completed radiotherapy for at least 3 months;
3. Those whose mouth-opening distance is less than or equal to 3.5 cm (the functional cut-off point of trismus) and who have tightness or pain in the masticatory muscles;
4. Medical condition is stable;

Exclusion Criteria:

1. Those who have undergone surgery on their masticatory muscles;
2. Patients with obvious muscle atrophy or complete fibrosis of masticatory muscles ;
3. Those with tumor recurrence at the time of admission;
4. Those whose vital signs are unstable due to acute illness.

Where it's running

• National Taiwan University Hospital
  Taipei, Taiwan Recruiting

Study contacts

• Study coordinator: Dr. Chen
• Email: b00401020@ntu.edu.tw
• Phone: +88623123456

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.