Using blood tests to predict cancer recurrence in endometrial cancer patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the effectiveness of liquid biopsies as a non-invasive method for detecting cancer cells in patients with various subtypes of endometrial cancer. It involves collecting blood and tissue samples from participants at different stages of treatment, including before and after surgery and during chemotherapy. The study will analyze genetic mutations in circulating cell-free DNA (ccfDNA) and compare these findings to traditional tumor sequencing. Additionally, it will explore the immune profile of the cancer and assess the presence of malignant cells in the vagina before and after surgery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Women age 18 years and older
* Histologic diagnosis of endometrial cancer
* Candidate for primary surgical treatment or has recently had prior primary surgery
* Willing and able to provide informed consent

Exclusion Criteria:

Patients who have received prior treatment including chemotherapy or radiation therapy for endometrial cancer. Prior hormonal therapy for the treatment of endometrial cancer is allowed. Patients with prior primary surgery will be allowed to enroll in this trial if the patient has not received any chemotherapy or radiation at the time of enrollment. Note: patients with a history of other cancers may be enrolled after discussion with the PI if it is determined that they are at low risk for recurrence or metastasis.

Where it's running

• M D Anderson Cancer Center
  Houston, Texas, United States Recruiting

Study contacts

• Principal investigator: Pamela T Soliman — M.D. Anderson Cancer Center
• Study coordinator: Pamela T Soliman, MD
• Email: psoliman@mdanderson.org
• Phone: 713-745-2352

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.