Using blood tests to improve ovarian cancer diagnosis
Improved Diagnosis of Ovarian Cancer by Use of Circulating Tumor DNA as a Biomarker
This study is testing whether a blood test that looks for tumor DNA can help doctors better tell if women with suspected ovarian cancer have a serious condition or not before they have surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 300 (estimated) |
| Ages | 18 Years and up |
| Sex | Female |
| Sponsor | University of Aarhus Academic / other |
| Locations | 1 site (Aarhus) |
| Trial ID | NCT05763511 on ClinicalTrials.gov |
What this trial studies
This project investigates the use of circulating tumor DNA (ctDNA) in women with suspected ovarian cancer to enhance diagnostic accuracy. The study aims to evaluate the effectiveness of ctDNA alone and in combination with imaging techniques and CA 125 levels for distinguishing between benign and malignant ovarian masses before surgery. Blood and tissue samples will be collected from participants to analyze disease progression and biology, ultimately leading to the development of a more effective diagnostic algorithm.
Who should consider this trial
Good fit: Ideal candidates are women with suspected ovarian neoplasms who can provide informed consent.
Not a fit: Patients with a previous diagnosis of ovarian cancer or those unable to give informed consent may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to earlier and more accurate diagnoses of ovarian cancer, improving patient outcomes.
How similar studies have performed: Other studies have shown promise in using ctDNA as a biomarker for various cancers, suggesting potential success for this approach in ovarian cancer diagnostics.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Suspected ovarian neoplasm * Informed consent Exclusion Criteria: * Inability to give informed consent * Previous ovarian cancer diagnosis
Where this trial is running
Aarhus
- Department of Gynaecology and Obstetrics, Aarhus University Hospital — Aarhus, Denmark (Recruiting)
Study contacts
- Principal investigator: Ina Marie Dueholm Hjorth, MD — University of Aarhus
- Study coordinator: Ina Marie Dueholm Hjorth, MD
- Email: imhjorth@gmail.com
- Phone: +4526192456
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.