Using bile analysis to diagnose unclear narrowings of the bile ducts

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study collects bile samples from adults with indeterminate biliary strictures at the time of ERCP and pairs those samples with biliary brush cytology and/or biopsy. Researchers will perform multi-omics screening on bile to identify molecular markers linked to biliary and pancreatic malignancies. Promising markers will be validated and used to build a bile-based molecular diagnostic model. The goal is to determine whether adding bile omics to current tissue sampling improves diagnostic sensitivity for malignant strictures.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Indeterminate biliary strictures
* Aged 18-90 years
* Underwent ERCP with biliary biopsy and/or brush cytology

Exclusion Criteria:

* Coagulation disorders
* Pregnancy
* Malignancies of other organs unrelated to biliary strictures
* Declined participation

Where it's running

• Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
  Shanghai, China, China Recruiting

Study contacts

• Study coordinator: Xiaobo Cai, MD
• Email: caixiaobo1979@hotmail.com
• Phone: 86+13918177123

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.