Clinical trial No longer in our active list Interventional Ages 40 to 75

Using big data to improve cardiovascular care

Official title: Using Big Data to Conduct Innovative Cardiovascular Clinical Trials: The Community Heart Outcomes Improvement and Cholesterol Education Study (CHOICES)

Run by Institute for Clinical Evaluative Sciences · NCT04067297 · Data updated 2026-05-14

This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.

This study is testing whether using big data can help doctors better manage cholesterol levels in people aged 40 to 75 in Ontario to prevent heart attacks and strokes.

Quick facts

Study typeInterventional
Ages40 Years to 75 Years
SexAll
Enrollment500000 (estimated)
SponsorInstitute for Clinical Evaluative Sciences
Academic / other
Locations1 site (Toronto, Ontario)
Trial IDNCT04067297 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are individuals aged 40 to 75 living in communities with higher than average cardiovascular disease incidence rates.

Probably not a fit

Patients with established cardiovascular disease will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to enhance the management of cardiovascular diseases by utilizing big data to conduct a pragmatic, cluster randomized trial. It focuses on communities in Ontario with high rates of cardiovascular events and implements a multicomponent intervention strategy to improve lipid management among individuals aged 40 to 75. By leveraging routinely collected health information, the study seeks to increase the use of cholesterol-lowering statin drugs to prevent heart attacks and strokes. The approach addresses the limitations of traditional clinical trials by applying real-world data to measure outcomes effectively.

Why it matters

Potential benefit: If successful, this study could significantly reduce the incidence of heart attacks and strokes in high-risk populations through improved lipid management.

How similar studies have gone: Other studies utilizing big data approaches have shown promise in improving health outcomes, suggesting that this methodology could be effective in this context as well.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Community with CVD incidence rates higher than the Ontario provincial average
* Community with a population size greater than 5,000 40 to 75 year olds
* Community with at least 1,000 66 to 75 year olds
* Community with 20 to 130 active and practicing family physicians

Exclusion Criteria:

* Patients with established CVD within each community

Where it's running

  • Ices
    Toronto, Ontario, Canada
    Recruiting

Study contacts

  • Principal investigator: Jacob A Udell, MD, MPH, FRCPC — ICES; Women's College Hospital; Peter Munk Cardiac Centre, Toronto General Hospital; University of Toronto
  • Study coordinator: Shalane R Basque, MSc
  • Email: shalane.basque@ices.on.ca
  • Phone: 4165799339

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.