Using autofluorescence imaging during surgery for primary hyperparathyroidism
Use of Intraoperative Autofluorescence Imaging in Surgery for Primary Hyperparathyroidism - a Randomized Controlled Trial.
NA · Aarhus University Hospital · NCT06230380
This study tests if using special imaging during surgery can help doctors find and remove the right parathyroid glands in patients with primary hyperparathyroidism.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Aarhus University Hospital (other) |
| Locations | 1 site (Aarhus) |
| Trial ID | NCT06230380 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of autofluorescence imaging as a surgical aid during parathyroidectomy for patients with primary hyperparathyroidism. The goal is to improve the identification of both normal and pathological parathyroid glands, which can be challenging during surgery. By utilizing this imaging technique, surgeons may enhance their ability to localize and remove the affected glands, potentially reducing the risk of persistent disease. The study involves patients who are scheduled for exploratory parathyroid surgery and will measure intraoperative parathyroid hormone levels.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old diagnosed with primary hyperparathyroidism who require exploratory parathyroidectomy.
Not a fit: Patients with concordant high-confidence imaging or those who have had previous thyroid or parathyroid surgeries may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to more effective surgeries and better outcomes for patients with primary hyperparathyroidism.
How similar studies have performed: While the use of autofluorescence imaging in surgery is gaining interest, this specific application in primary hyperparathyroidism is relatively novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age\>18 years and able to give informed consent. * A diagnosis of PHPT. * Planned exploratory PTX with ioPTH measurement. Exclusion Criteria: * Concordant high-confidence imaging; planned focused/selective PTX * Previous thyroid or parathyroid surgery. * Planned simultaneous thyroid surgery. * MEN, lithium induced hyperparathyroidism. * eGFR \< 30. * Kidney transplant.
Where this trial is running
Aarhus
- Aarhus University Hospital — Aarhus, Denmark (RECRUITING)
Study contacts
- Study coordinator: Jacob K Lilja-Fischer, MD
- Email: jaclil@rm.dk
- Phone: +4540460399
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Hyperparathyroidism, Primary