Using Astragalus to Treat Non-motor Symptoms in Parkinson's Disease
Efficacy and Safety of Astragalus for Non-Motor Symptoms of α-Synucleinopathy：an Open-Label Self-Controlled Before-and-After Study
This study is testing if astragalus can help people with Parkinson's disease feel better by easing non-motor symptoms like blood pressure issues when they stand up.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 30 Years to 85 Years |
| Sex | All |
| Sponsor | Fujian Medical University Union Hospital Academic / other |
| Locations | 1 site (Fuzhou, Fujian) |
| Trial ID | NCT05506891 on ClinicalTrials.gov |
What this trial studies
This study evaluates the efficacy and safety of astragalus in treating non-motor symptoms associated with α-synucleinopathy, particularly focusing on autonomic dysfunctions like orthostatic hypotension. It employs an open-label self-controlled before-and-after methodology, allowing participants to serve as their own controls. Participants will receive astragalus treatment alongside physical therapy, with outcomes measured before and after the intervention. The study aims to fill a gap in the current understanding of non-motor symptom management in neurodegenerative diseases.
Who should consider this trial
Good fit: Ideal candidates include adults diagnosed with Parkinson's disease, multiple system atrophy, or dementia with Lewy bodies who also experience orthostatic hypotension.
Not a fit: Patients with secondary Parkinsonism or those with other neurological disorders may not benefit from this study.
Why it matters
Potential benefit: If successful, this treatment could significantly improve the quality of life for patients suffering from non-motor symptoms of Parkinson's disease and related conditions.
How similar studies have performed: While there is limited research specifically on astragalus for non-motor symptoms, similar studies exploring herbal treatments for neurodegenerative conditions have shown promise.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participants with a clinical diagnosis of PD, MSA and DLB, with orthostatic hypotension. * Participants with cognitive disorder. * Adults signed informed consents. Exclusion Criteria: * Patients with history of astragalus allergy. * Patients with secondary Parkinsonism that cannot be excluded. * Patients with diseases that may cause other types of hypotension or similar symptoms/signs because of hypotension * Patients with other medical conditions requiring treatments that may affect blood pressure. * Patients with other neurological disorders. * Patients with serious comorbidities and immune diseases. * Uncooperative patients. * Pregnant or lactating women.
Where this trial is running
Fuzhou, Fujian
- Fujian Medical University Union Hospital — Fuzhou, Fujian, China (Recruiting)
Study contacts
- Study coordinator: Xiaodong Pan
- Email: pxd77316@163.com
- Phone: 0591-86218341
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.