Using Asiaticoside to treat infected teeth with apical periodontitis
Effectiveness of Asiaticoside as Intracanal Medication on Infectious/Inflammatory Contents in Teeth With Apical Periodontitis
PHASE2; PHASE3 · Mansoura University · NCT06566508
This study is testing if a new medication called Asiaticoside can better treat infected teeth with apical periodontitis compared to standard treatments.
Quick facts
| Phase | PHASE2; PHASE3 |
|---|---|
| Study type | Interventional |
| Enrollment | 36 (estimated) |
| Ages | 20 Years to 60 Years |
| Sex | All |
| Sponsor | Mansoura University (other) |
| Locations | 1 site (Al Mansurah) |
| Trial ID | NCT06566508 on ClinicalTrials.gov |
What this trial studies
This study investigates the effectiveness of Asiaticoside as an intracanal medication for treating teeth with apical periodontitis, comparing it to standard treatments like calcium hydroxide and Ledermix. The focus is on measuring the reduction of bacteria and inflammatory cytokines in the root canals and surrounding tissues. The study aims to provide clinical evidence on whether Asiaticoside can offer superior outcomes in managing this dental condition.
Who should consider this trial
Good fit: Ideal candidates are individuals with single-rooted teeth suffering from pulp necrosis and apical periodontitis.
Not a fit: Patients currently receiving antibiotic treatment, those with systemic diseases, or teeth that cannot be isolated may not benefit from this study.
Why it matters
Potential benefit: If successful, this treatment could lead to more effective management of infections in teeth with apical periodontitis, improving patient outcomes.
How similar studies have performed: While the use of intracanal medications is common, the specific application of Asiaticoside in this context is novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: • Single-rooted with pulp necrosis and apical periodontitis. Exclusion Criteria: Receiving antibiotic treatment within the preceding 3 months. * Reporting systemic disease. * Teeth that could not be isolated with rubber dam. * Teeth with periodontal pockets deeper than 3 mm.
Where this trial is running
Al Mansurah
- Mansoura university — Al Mansurah, Egypt (RECRUITING)
Study contacts
- Study coordinator: salem alqahtani, master
- Email: Salemamq@gmail.com
- Phone: 00201553553096
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Intracanal Medication, Inflammation, Asiaticoside, Pulpal necrosis