Using arterial pressure to assess fluid responsiveness in critically ill patients
The Performance of Changes of Pulse Pressure and of Pulse Pressure Variation to Detect Preload Responsiveness in Spontaneously Breathing Patients
This study is testing if measuring blood pressure changes during a leg raise can help doctors figure out if critically ill patients need more fluids.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 30 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | CHU de Reims Academic / other |
| Locations | 1 site (Reims) |
| Trial ID | NCT06480942 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the effectiveness of pulse pressure variation (PPV) and pulse pressure (PP) measurements during a passive leg raising (PLR) maneuver to predict fluid responsiveness in spontaneously breathing patients in intensive care. The study will involve critically ill patients who are being monitored for hemodynamic instability and may require fluid infusion. Continuous arterial pressure monitoring will be utilized to collect data before and after the PLR maneuver, allowing for a comparison of changes in hemodynamic parameters. The primary objective is to assess the diagnostic performance of these parameters in predicting preload responsiveness.
Who should consider this trial
Good fit: Ideal candidates include critically ill patients over 18 years old, hospitalized in intensive care, and requiring assessment for fluid responsiveness.
Not a fit: Patients with arrhythmias, intra-abdominal hypertension, or contraindications to the PLR maneuver may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve fluid management in critically ill patients, potentially enhancing their recovery and outcomes.
How similar studies have performed: Other studies have shown promise in using similar approaches to assess fluid responsiveness, indicating potential for success in this study.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient over 18 years old. * Hospitalized in intensive care. * For which the clinician in charge of the patient will need to predict the response to fluids and decide on a possible infusion of fluids, because of: * Acute circulatory failure with mean arterial pressure \< 65mmHg or \< 30mmHg of its baseline value for hypertensive patients. * And/or other signs of hemodynamic instability (tachycardia, mottling, oliguria, hyperlactatemia) : * In spontaneous ventilation and without ventilatory assistance. * Previously equipped with an arterial catheter. * Affiliated to a social security scheme. Exclusion Criteria: * Patient with arrythmia (PPV is not applicable). * Patient with intra-abdominal hypertension (PLR test is not valid). * Patient with a contraindication/impossibility to the PLR maneuver (lower limb amputation, respiratory intolerance). * Patient with poor echogenicity noted previously. * Patient protected by law.
Where this trial is running
Reims
- Chu Reims — Reims, France (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.